MSH2
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Official Full Name
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) -
Overview
The MSH2 gene is one of at least 4 genes encoding proteins involved in the repair of mismatch nucleotides following DNA replication or repair. Mutations in the MSH2 gene contribute to the development of sporadic colorectal carcinoma,While germline MSH2 mutations are responsible for approximately 50% of inherited, non-polyposis colorectal carcinoma (HNPCC). MSH2 encodes a protein of 934 amino acids. -
Synonyms
MSH2;mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli);COCA1, mutS (E. coli) homolog 2 (colon cancer, nonpolyposis type 1);DNA mismatch repair protein Msh2;HNPCC;HNPCC1;hMSH2;FCC1;COCA1;LCFS2
Recombinant Proteins
- Mouse
- Zebrafish
- Human
- Rat
- Pig
- Mammalian Cells
- E.coli
- Wheat Germ
- HEK293
- Insect Cells
- In Vitro Cell Free System
- His
- Non
- GST
- DDK&Myc
- GST&His
- Avi&Fc&His
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MSH2-10131M | Recombinant Mouse MSH2 Protein | Mammalian Cells | Mouse | His |
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| MSH2-12683Z | Recombinant Zebrafish MSH2 | Mammalian Cells | Zebrafish | His |
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| MSH2-162H | Recombinant Human MSH2 | E.coli | Human | Non | 735-934 a.a. |
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| MSH2-28175TH | Recombinant Human MSH2 protein, GST-tagged | Wheat Germ | Human | GST | 1-934 a.a. |
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| MSH2-28793TH | Recombinant Human MSH2 | Wheat Germ | Human | Non | 100 amino acids |
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| MSH2-3787R | Recombinant Rat MSH2 Protein | Mammalian Cells | Rat | His |
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| MSH2-493H | Recombinant Human MSH2 protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| MSH2-621H | Recombinant Human MSH2 Protein, His&GST-tagged | Insect Cells | Human | GST&His | 1-934 a.a. |
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| MSH2-4120HCL | Recombinant Human MSH2 293 Cell Lysate | HEK293 | Human | Non |
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| MSH2-1137H | Recombinant Human MSH2 Protein, His-tagged | HEK293 | Human | His | Ala2-Asp140 |
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| MSH2-1138P | Recombinant Pig MSH2 Protein, His-tagged | E.coli | Pig | His | Asn535-Thr934 |
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| MSH2-2456H | Recombinant Human MSH2 Protein, His-tagged | E.coli | Human | His | Asn535-Thr934 |
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| MSH2-2763H | Recombinant Human MSH2 protein(441-610 aa), C-His-tagged | E.coli | Human | His | 441-610 aa |
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| MSH2-3446R | Recombinant Rat MSH2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| MSH2-3446R-B | Recombinant Rat MSH2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Msh2-4186M | Recombinant Mouse Msh2 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| MSH2-5739M | Recombinant Mouse MSH2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| MSH2-5739M-B | Recombinant Mouse MSH2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| MSH2-6982HF | Recombinant Full Length Human MSH2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 934 amino acids |
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| MSH2-8544HFL | Recombinant Full Length Human MSH2 protein, Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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Involved Pathway
MSH2 involved in several pathways and played different roles in them. We selected most pathways MSH2 participated on our site, such as Mismatch repair,Pathways in cancer,Colorectal cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MSH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mismatch repair | POLD2,MLH1,SSBP1,POLD4,MSH3,RFC1,RFC2,LIG1,POLD1,RPA4 |
| Pathways in cancer | Flt3l,PIK3R1,FGF11,LAMB4,PRKCA,PLCB3,RXRB,PIK3CG,STAT3,WNT16 |
| Colorectal cancer | ARAF,PIK3R3,BAD,MAPK9,AKT1,PIK3CB,MAP2K1,RAC2,MLH1,LEF1 |
Protein Function
MSH2 has several biochemical functions, for example, contributes_to ADP binding,contributes_to ATP binding,contributes_to ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MSH2 itself. We selected most functions MSH2 had, and list some proteins which have the same functions with MSH2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ADP binding | MSH6,ATP5D |
| protein binding | STAT2,HSPB11,INTS10,PPIL2,PPCDC,XPO5,NME4,TTN,OGT,EGR1 |
| contributes_to guanine/thymine mispair binding | MSH6 |
| contributes_to oxidized purine DNA binding | MSH6 |
| contributes_to single thymine insertion binding | MSH6 |
| contributes_to double-stranded DNA binding | APITD1,MSH6,STRA13 |
| contributes_to dinucleotide repeat insertion binding | MSH3 |
| contributes_to mismatched DNA binding | MSH3,MSH6 |
| contributes_to single guanine insertion binding | MSH3,MSH6 |
Interacting Protein
MSH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MSH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MSH2.
MSH6;SLX4;EXO1;E2F3;BRCA1
Resources
Research Area
Tumor SuppressorsDNA Damage and Repair
Ovarian Cancer Biomarkers
Pancreatic Cancer Biomarkers
Other DNA Repair
Related Services
Related Products
References
- Stark, AM; Doukas, A; et al. Expression of DNA mismatch repair proteins MLH1, MSH2, and MSH6 in recurrent glioblastoma. NEUROLOGICAL RESEARCH 37:95-105(2015).
- Jentzsch, T; Robl, B; et al. Expression of MSH2 and MSH6 on a Tissue Microarray in Patients with Osteosarcoma. ANTICANCER RESEARCH 34:6961-6972(2014).
