Recombinant Mouse Kcnj6 (consisting of residues 52-380, constitutively active mutant)

• Cat.No.: Kcnj6-9171M
• Product Overview: Recombinant Mouse Kcnj6 (consisting of residues 52-380 , constitutively active mutant), was expressed in Pichia pastoris and purified by Affinity chromatography, Superdex-200 gel filtration.

Specification

• Species: Mouse
• Source: P.pastoris
• Tag: Non
• Protein Length: 329 amino acids(residues 52-380)
• Description: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and may be involved in the regulation of insulin secretion by glucose. It associates with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex.
• Form: 20 mM Tris-HCl (pH 7.5), 150 mM KCl, 0.2% (w/v) DM ,20 mM DTT, and 1 mM EDTA
• Molecular Mass: Predicts a molecular mass of 37KDa. As a result of transmembrane protein, it migrates approximately 33～40 KDa in SDS-PAGE under non-reducing conditions.
• Purity: >95% as determined by SDS-PAGE
• Storage: Can be stored at +4℃ short term. For long term storage, store at -20℃
• Concentration: 0.54 mg/ml

Gene Information

• Gene Name: Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 [ Mus musculus ]
• Official Symbol: Kcnj6
• Synonyms: KCNJ6; potassium inwardly-rectifying channel, subfamily J, member 6; G protein-activated inward rectifier potassium channel 2; GIRK-2; inward rectifier K(+) channel Kir3.2; potassium inwardly-rectifying channel J6; potassium channel, inwardly rectifying subfamily J member 6; wv; BIR1; GIRK2; KATP2; KCNJ7; Kir3.2; weaver
• Gene ID: 16522
• mRNA Refseq: NM_001025584
• Protein Refseq: NP_001020755
• Pathway: Activation of G protein gated Potassium channels, organism-specific biosystem; Activation of GABAB receptors, organism-specific biosystem; Cholinergic synapse, organism-specific biosystem; Dopaminergic synapse, organism-specific biosystem; Dopaminergic synapse, conserved biosystem; G protein gated Potassium channels, organism-specific biosystem; GABA B receptor activation, organism-specific biosystem
• Function: G-protein activated inward rectifier potassium channel activity; G-protein alpha-subunit binding; inward rectifier potassium channel activity; ion channel activity; voltage-gated ion channel activity