Recombinant Human CLIC5, His-tagged

• Cat.No.: CLIC5-7653H
• Product Overview: Recombinant Human Chloride Intracellular Channel Protein 5/CLIC5 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1Ser251) of Human CLIC5 fused with a His tag at the Cterminus.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Chloride Intracellular Channel Protein 5 (CLIC5) is a singlepass membrane protein which belongs to the chloride channel CLIC family. It contains one GST Cterminal domain. Chloride intracellular channels are involved in chloride ion transport within various subcellular compartments. CLIC5 can insert into membranes and form selective ion channels regulated by actin that may transport chloride ions. It may play a role in the regulation of transepithelial ion absorption and secretion. CLIC5 specifically associates with the cytoskeleton of placenta microvilli. CLIC5 is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture.
• Form: Lyophilized from a 0.2 μM filtered solution of 20mM PB, 150mM NaCl, pH 7.4
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MTDSATANGD DRDPEIELFV KAGIDGESIG NCPFSQRLFM ILWLKGVVF NVTTVDLKRK PADLHNLAPG THPPFLTFNG DVKTDVNKIE EFLEETLTPE K YPKLAAKH RESNTAGIDI FSKFSAYIKN TKQQNNAALE RGLTKALKKL DDYLNTPLPE EI DANTCGE DKGSRRKFLD GDELTLADCN LLPKLHVVKI VAKKYRNYDI PAEMTGLWRY LKN AYARDE FTNTCAADSE
• Purity: Greater than 95% as determined by reducing SDS-PAGE.
• Notes: For research use only.
• Storage: Lyophilized protein should be stored at less than 20°C. though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C. for 2-7 days.Aliquots of reconstituted samples are stable at less than 20°C. for 3 months.

Gene Information

• Gene Name: CLIC5 chloride intracellular channel 5 [ Homo sapiens ]
• Official Symbol: CLIC5
• Synonyms: CLIC5; chloride intracellular channel 5; chloride intracellular channel protein 5; MST130; MSTP130; FLJ90663
• Gene ID: 53405
• mRNA Refseq: NM_001114086
• Protein Refseq: NP_001107558
• MIM: 607293
• UniProt ID: Q9NZA1
• Chromosome Location: 6p12.3
• Function: protein binding; voltage-gated chloride channel activity; voltage-gated ion channel activity