Active Recombinant Rhesus CCL17 protein, His-tagged

• Cat.No.: CCL17-858R
• Product Overview: A DNA sequence encoding the rhesus CCL17 (Met1-Ser94) was expressed with a polyhistidine tag at the C-terminus.

Specification

• Species: Rhesus macaque
• Source: Insect Cells
• Tag: His
• Protein Length: Met1-Ser94
• Description: Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved locations in order to form their 3-dimensional shape. Some of the chemokines are considered pro-inflammatory which can be induced to recruit cells of the immune system to a site of infection during an immune response, while others are considered homeostatic and are implied in controlling the migration of cells during normal processes of tissue maintenance and development. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands-1 to 28. Chemokin ligand 17 (CCL17), also known as thymus and activation regulated chemokine(TARC), is a small cytokine belonging to the C-C chemokine family. CCL17 is expressed maily in thymus and transiently in phytohemagglutinin-stimulated peripheral blood mononuclear cells. CCL17 can induce chemotaxis in T cells by binding with the chemokine receptor CCR4.
• Predicted N Terminal: Ala 24
• Form: Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly
  Please contact us for any concerns or special requirements.
  Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Bio-activity: Testing in progress
• Molecular Mass: The recombinant rhesus CCL17 comprises 81 amino acids and has a calculated molecular mass of 9.5 KDa.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Stability: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C
• Storage: Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
  Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Gene Information

• Gene Name: CCL17 C-C motif chemokine ligand 17 [ Macaca mulatta (Rhesus monkey) ]
• Official Symbol: CCL17
• Synonyms: CCL17
• Gene ID: 574180
• mRNA Refseq: XM_015126152.2
• Protein Refseq: XP_014981638.1
• UniProt ID: Q8HYP9