Active Recombinant Mouse Vsig4 Protein, Fc Chimera

• Cat.No.: Vsig4-861M
• Product Overview: Recombinant Mouse Vsig4 (Accession # NP_808457), fused with , was produced in Mouse myeloma cell line, NS0-derived.

Specification

• Source: Mammalian cells
• Species: Mouse
• Tag: Fc
• Predicted N Terminal: His20
• Form: Lyophilized from a 0.2 µm filtered solution in PBS.
• Bio-activity: Measured by its ability to inhibit anti-CD3-induced proliferation of splenic T lymphocytes. Vogt, L. et al. (2006) J. Clin. Invest. 116:2817.The presence of immobilized rmVSIG4/Fc Chimera inhibited the anti-CD3 response by 50% - 70%. The ED50 for this effect is typically 1.25 - 5 µg/mL.Measured by its ability to bind human iC3b in a functional ELISA. Optimal dilutions should be determined by each laboratory for each application.
• Molecular Mass: Recombinant Mouse Vsig4, Fc Chimera has a calculated MW of 46 kDa (monomer). In SDS-PAGE migrates as 60-65 kDa, reducing conditions.
• Purity: >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).

Gene Information

• Gene Name: Vsig4 V-set and immunoglobulin domain containing 4 [ Mus musculus ]
• Official Symbol: Vsig4
• Synonyms: VSIG4; V-set and immunoglobulin domain containing 4; V-set and immunoglobulin domain-containing protein 4; complement receptor of the immunoglobulin superfamily; CRIg; Z39IG; BC025105; A530061A11; MGC36211
• Gene ID: 278180
• mRNA Refseq: NM_177789
• Protein Refseq: NP_808457

Reviews

11/08/2021

Stable performance, excellent performance in a variety of experiments.

10/01/2021

No side effects, high safety.

03/13/2021

It has good antigenicity and can induce target immune response.

Q&As

What is the relationship of VSIG4 to other genes or proteins?

VSIG4 has a complex relationship with other genes or proteins, and can interact with other genes or proteins and participate in a variety of biochemical reactions.

How can the disease be treated by regulating the levels of VSIG4?

There are no drugs that directly regulate VSIG4 levels, but they can affect VSIG4 expression and function by modulating the immune system.

How to detect and analyze mutations in VSIG4?

Mutations in VSIG4 can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.

What is the specific role of VSIG4 in tumor immunity?

VSIG4 plays an important role in tumor immunity, which can inhibit the activation and function of T cells and NK cells, thereby promoting tumor growth and metastasis.

How to study the regulatory mechanism of VSIG4?

Studying the regulatory mechanism of VSIG4 requires a combination of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.

What are the mutation types of VSIG4?

The types of mutations in VSIG4 include point mutations, insertions/deletions, duplications, etc., which can cause structural and functional abnormalities of the protein.