Active Recombinant Mouse RANK L Protein

• Cat.No.: RANK L-547M
• Product Overview: Recombinant Mouse RANK L Protein(NP_033425.3) was expressed in E.coli.

Specification

• Species: Mouse
• Source: E.coli
• Tag: Non
• Description: Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is a member of the TNF superfamily. RANKL also has a function in the immune system, where it is expressed by T helper cells and is thought to be involved in dendritic cell maturation. The murine TRANCE cDNA encodes a type II transmembrane protein of 316 amino acids with a predicted cytoplasmic domain of 48 amino acids and extracellular of 247 amino acids. Mouse and human TRANCE share 85% amino acid sequence identity. TRANCE is primarily expressed in T cells and T cell rich organs, such as thymus and lymph nodes.
• Predicted N Terminal: Met
• Bio-activity: The ED50 for this effect is typically 0.5-2ng/ml
• Endotoxin: <0.01 EU/µg of the protein
• Purity: >95% by SDS-PAGE gel under reducing conditions and visualized by silver stain.
• Reconstitution: 400ng/µl in sterile PBS.

Gene Information

• Gene Name: Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a, NFKB activator [ Mus musculus (house mouse) ]
• Official Symbol: Tnfrsf11a
• Synonyms: R; OFE; ODFR; Rank; TRAN; Ly109; mRANK; TRANCE-R
• Gene ID: 21934
• mRNA Refseq: NM_009399.4
• Protein Refseq: NP_033425.3
• UniProt ID: O35305