Active Recombinant Mouse PVRIG protein, Fc-tagged
Cat.No. : | PVRIG-12M |
Product Overview : | The extracellular domain of mouse CD112R (aa 28-165) fused with the C-terminus to the Fc portion of human IgG1 was expressed in HEK 293 cells. |
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Species : | Mouse |
Source : | HEK293 |
Tag : | Fc |
Protein Length : | 28-165 a.a. |
Description : | CD112 (also called Nectin-2 or poliovirus receptor-related 2 protein) is a type I transmembrane glycoprotein and a member of the Ig gene superfamily (IGSF). CD112/Nectin-2 functions as an adhesion molecule involved in the formation of cell junctions and interactions with other Nectin-family molecules. Nectin-2 is a also a surface marker of some endothelial cells and regulates migration, proliferation and angiogenesis. CD112 functions as an immune checkpoint regulator by modulating T cell signaling, either as a costimulator of T cell function, or as a coinhibitor of T cells proliferation by binding to the receptors CD226 or TIGIT (T cell Ig and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain), respectively. The binding of CD112 ligand to these receptors is weak compared to CD155. Recently, a new receptor of CD112, called CD112R or PVRIG (Poliovirus receptor-related immunoglobulin domain-containing protein) has been characterized, showing high affinity to CD112. CD112R is a new coinhibitory receptor of the PVR family for human T cells, inhibiting TCR-mediated signals upon binding to CD112/Nectin-2. CD112R is preferentially expressed in T lymphocytes and NK cells. Cancer cells evade immune responses as a result of an immunosuppressive tumor microenvironment and CD112R, by playing a role in the regulation of the immune system, could be a new attractive cancer immunotherapy target. |
Form : | Lyophilized. Contains PBS. |
Bio-activity : | Binds to the ligand mouse CD112 (PVRL2, Nectin-2) with an EC50 of 5nM. |
Molecular Mass : | ~48-50 kDa (SDS-PAGE) |
Endotoxin : | <0.01EU/μg purified protein (LAL test) |
Purity : | >90% (SDS-PAGE) |
Stability : | Stable for at least 6 months after receipt when stored at -20 centigrade. |
Storage : | Short term store at +4 centigrade, store at -20 centigrade for long term storage. |
Concentration : | 0.1mg/mL after reconstitution. |
Reconstitution : | Reconstitute with 100 μL sterile water. |
Handling : | After reconstitution, prepare aliquots and store at -20 centigrade. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions. |
Gene Name | poliovirus receptor related immunoglobulin domain containing [ Mus musculus (house mouse) ] |
Official Symbol | Pvrig |
Synonyms | CD112 Receptor; Poliovirus Receptor-related Immunoglobulin Domain-containing Protein; Transmembrane Protein PVRIG |
Gene ID | 102640920 |
mRNA Refseq | XM_011240963.2 |
Protein Refseq | XP_011239265.1 |
UniProt ID | A0A1B0GS01 |
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◆ Cell & Tissue Lysates | ||
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Not For Human Consumption!
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