Active Recombinant Human PVRIG Protein, Fc-Avi-tagged, Biotinylated

• Cat.No.: PVRIG-617HB
• Product Overview: Biotinylated Human PVRIG, Fc, Avi tag is expressed from human 293 cells (HEK293). It contains AA Thr 41-Asp 171 (Accession # Q6DKI7-1).

Specification

• Species: Human
• Source: HEK293
• Tag: Avi&Fc
• Protein Length: Thr 41-Asp 171
• Description: Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The CD112R gene encodes a putative single transmembrane protein, which is composed of a single extracellular IgV domain, one transmembrane domain, and a long intracellular domain. Notably, the intracellular domain of phatases. The extracellular domain sequence of human and mouse CD112R have 65.3% similarity. CD112R may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.
• Predicted N Terminal: Thr 41
• Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose.
• Molecular Mass: The protein has a calculated MW of 41.9 kDa. The protein migrates as 50-58 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: >90% as determined by SDS-PAGE.
• Storage: For long term storage, the product should be stored at lyophilized state at -20°C or lower.
  Please avoid repeated freeze-thaw cycles.
  This product is stable after storage at:
  -20°C to -70°C for 12 months in lyophilized state;
  -70°C for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: PVRIG
• Official Symbol: PVRIG
• Synonyms: C7orf15, C7orf15MGC138295, CD112R, MGC104322, MGC138297, MGC2463, P VRIG, CD112 receptor
• Gene ID: 79037
• mRNA Refseq: NM_024070.3
• Protein Refseq: NP_076975.2
• MIM: 617012
• UniProt ID: Q6DKI7