Active Recombinant Mouse Jag1, Fc-tagged

• Cat.No.: Jag1-381M
• Product Overview: Signal peptide and extracellular domain of mouse Jagged-1 (aa 1-1067) are fused at the C-terminus to the Fc portion of human IgG.

Specification

• Species: Mouse
• Source: HEK293
• Tag: Fc
• Protein Length: 1-1067 a.a.
• Description: Jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. It is involved in cell-fate decisions during hematopoiesis. Is involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Defects in Jagged-1 are the cause of Alagille syndrome type 1 (ALGS1) and tetralogy of Fallot (TOF).
• Form: Liquid. 0.2μm-filtered solution in PBS.
• Bio-activity: Inhibits adipogenesis of 3T3L-1 cells.
• Molecular Mass: ~150kDa (SDS-PAGE)
• Purity: ≥90% (SDS-PAGE)
• Stability: Working aliquots are stable for up to 3 months when stored at -20°C.
• Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
• Publications:
  Pulmonary-delivered Anticalin Jagged-1 antagonists reduce experimental airway mucus hyperproduction and obstruction (2025)

Gene Information

• Gene Name: Jag1 jagged 1 [ Mus musculus ]
• Official Symbol: Jag1
• Synonyms: JAG1; jagged 1; protein jagged-1; Serrate-1; Htu; Ozz; ABE2; Ser-1; Gsfabe2
• Gene ID: 16449
• mRNA Refseq: NM_013822
• Protein Refseq: NP_038850
• Pathway: Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Notch Signaling Pathway, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem; Notch signaling pathway, conserved biosystem; Signal Transduction, organism-specific biosystem; Signaling by NOTCH, organism-specific biosystem
• Function: Notch binding; calcium ion binding; protein binding