Active Recombinant Mouse Il6, Fc-tagged

• Cat.No.: Il6-321M
• Product Overview: The extracellular domain of mouse IL-6 (aa 1-211) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a.

Specification

• Species: Mouse
• Source: CHO
• Tag: Fc
• Protein Length: 1-211 a.a.
• Description: Interleukin 6 (IL-6) is a pleiotropic alpha-helical cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism and cancer progression. IL-6 activity is essential for the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. It is secreted by multiple cell types as a 22kDa-28kDa phosphorylated and variably glycosylated molecule. IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6R) and a signal transducing subunit (gp130). IL-6 is a key factor for the growth of plasma cells.
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Shows the biological function of the IL-6 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
• Purity: ≥98% (SDS-PAGE)
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. Avoid freeze/thaw cycles.

Gene Information

• Gene Name: Il6 interleukin 6 [ Mus musculus ]
• Official Symbol: Il6
• Synonyms: IL6; interleukin 6; interleukin-6; interleukin HP-1; B-cell hybridoma growth factor; Il-6
• Gene ID: 16193
• mRNA Refseq: NM_031168
• Protein Refseq: NP_112445
• Pathway: Adipogenesis, organism-specific biosystem; African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem
• Function: cytokine activity; cytokine activity; growth factor activity; interleukin-6 receptor binding; interleukin-6 receptor binding; protein binding; receptor binding