Active Recombinant Mouse IL23R protein, His-tagged

• Cat.No.: IL23R-135M
• Product Overview: Recombinant Mouse IL23R protein(Q8K4B4)(Gly24-Gly374), fused with His tag, was expressed in HEK293.

Specification

• Source: HEK293
• Species: Mouse
• Tag: His
• Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4.
• Bio-activity: IL-23 (mouse):FC (human) (rec.) captured on Protein A chip, can bind Recombinant Mouse IL-23R/His Protein with a KD constant of 1.55E-06 M, determined in a SPR assay.
• Molecular Mass: The protein has a calculated MW of 41kDa.The reducing (R) heterodimer protein migrates as 60-100 kDa due to glycosylation
• Protein length: Gly24-Gly374
• Endotoxin: <1EU/mg
• Purity: SDS-PAGE>90%，SEC>95%
• Storage: Store at -20°C.
• Reconstitution: sterile H54O

Gene Information

• Gene Name: Il23r interleukin 23 receptor [ Mus musculus ]
• Official Symbol: IL23R
• Synonyms: IL23R; interleukin 23 receptor; interleukin-23 receptor; IL-23 receptor; IL-23R
• Gene ID: 209590
• mRNA Refseq: NM_144548
• Protein Refseq: NP_653131

Reviews

10/21/2020

High specificity in ELISA.

04/28/2016

Effective in autoimmune models.

03/30/2016

Suitable for receptor binding studies.

Q&As

How does IL23R activation affect T-cell differentiation?

IL23R activation promotes Th17 cell differentiation.

Does IL23R have alternative splicing variants?

IL23R has multiple alternative splicing variants.

Does IL23R have any post-translational modifications that affect its stability?

IL23R undergoes phosphorylation that affects its stability.

What is the half-life of IL23R protein in activated T-cells?

The half-life of IL23R protein in activated T-cells is approximately 48 hours.

Are there any microRNAs that regulate IL23R expression?

MicroRNAs like miR-20a regulate IL23R expression.

How does IL23R contribute to cytokine release?

IL23R contributes to the release of pro-inflammatory cytokines like IL-17.

What role does IL23R play in autoimmune diseases?

IL23R is implicated in autoimmune diseases like Crohn's.

How does IL23R expression change during infection?

IL23R expression is upregulated during bacterial infection.

Does IL23R form homodimers or heterodimers?

IL23R forms heterodimers with IL-12Rβ1.

What intracellular pathways are activated by IL23R?

IL23R activates the JAK-STAT and NF-κB pathways.