Active Recombinant Mouse Cardiotrophin 1

• Cat.No.: Ctf1-342M
• Product Overview: Recombinant Mouse Ctf1 was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Cat. No.: Ctf1-342M
• Description: CT-1 is a member of the IL6 family of cytokines which also includes LIF, CNTF, OSM (Oncostatin M), IL11, IL6 and possibly NNT-1/ BCSF-3. CT-1 is a pleiotropic cytokine which is expressed in various tissues including the adult heart, skeletal muscle, ovary, colon, prostate and fetal lung and signals through the LIF receptor and the gp130 receptor subunit. CT-1 has the ability to induce cardiac myocyte hypertrophy, and enhances the survival of cardiomyocyte and different neuronal populations.
• Source: Mouse
• Host: E.coli
• Form: Supplied as a lyophilized powder.
• Purity: >98% pure by SDS PAGE and HPLC
• Sequence: Region of Cardiotrophin 1 protein corresponding to amino acids SQREGSLEDH QTDSSISFLP HLEAKIRQTH NLARLLTKYA EQLLEEYVQQ QGEPFGLPGF SPPRLPLAGL SGPAPSHAGL PVSERLRQDA AALSVLPALL DAVRRRQAEL NPRAPRLLRS LEDAARQVRA LGAAVETVLA ALGAAARGPG PEPVTVATLF TANSTAGIFS AKVLG
• Molecular Mass: 21.3 kDa
• Applications: Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions
• Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Bioactivity: The ED50 as determined by the dose-dependent proliferation of TF-1 cells was <1.0 ng/ml, corresponding to a specific activity of >1 x 10^6units/mg.
• Storage: Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
• Tag: Non

Gene Information

• Gene Name: Ctf1 cardiotrophin 1 [ Mus musculus ]
• Official Symbol: Ctf1
• Synonyms: Ctf1; CT-1; cardiotrophin-1
• Gene ID: 13019
• mRNA Refseq: NM_007795
• Protein Refseq: NP_031821
• UniProt ID: Q60753
• Chromosome Location: 7; 7 F3
• Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; MicroRNAs in cardiomyocyte hypertrophy
• Function: cytokine activity; leukemia inhibitory factor receptor binding