Active Recombinant Mouse BDNF protein, His-tagged

Cat.No. : BDNF-9843M
Product Overview : A DNA sequence encoding the mouse BDNF (EDL27780.1, with mutation Arg 129 Ala, Arg 130 Ala) (Met1-Arg249) was expressed with a polyhistidine tag at the C-terminus.
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Species : Mouse
Source : HEK293
Tag : His
Protein Length : Met1-Arg249
Description : BDNF is a member of the nerve growth factor family. It is highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. It also can be detected in heart, lung, skeletal muscle, testis, prostate and placenta. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. During development, BDNF promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. It participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. It functions as the major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
Predicted N Terminal : Ala 19
Form : Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Bio-activity : Testing in progress
Molecular Mass : The recombinant mouse BDNF consists of 242 amino acids and predicts a molecular mass of 27.4 kDa.
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : > 95% as determined by SDS-PAGE.
Stability : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C
Storage : Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 mg/ml. Centrifuge the vial at 4°C before opening to recover the entire contents.
Shipping : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Gene Name Bdnf brain derived neurotrophic factor [Mus musculus (house mouse)]
Official Symbol BDNF
Synonyms BDNF
Gene ID 12064
mRNA Refseq NM_001048139.1
Protein Refseq NP_001041604.1
UniProt ID P21237

Not For Human Consumption!

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