Active Recombinant Monkey TNFRSF9 Protein, His-tagged, Alexa Fluor 647 conjugated
Cat.No. : | TNFRSF9-550RAF647 |
Product Overview : | Alexa Fluor 647 conjugated recombinant Rhesus TNFRSF9 (NP_001253057.1) (Met1-Gln186) was expressed with a polyhistidine tag at the C-terminus. |
Availability | February 22, 2025 |
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Species : | Monkey |
Source : | HEK293 |
Tag : | His |
Protein Length : | Met1-Gln186, 174 |
Description : | CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymph centigradeytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is ass centigradeiated with the tumor necrosis factor receptor–ass centigradeiated factors (TRAFs), the adaptor protein which mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as mon centigradeyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses. In addition, CD137 and CD137L are expressed in different human primary tumor tissues, suggesting that they may influence the progression of tumors. Crosslinking of CD137 on activated T cells has shown promise in enhancing anti-tumor immune responses in murine models, and agonistic anti-CD137 antibodies are currently being tested in phase I clinical trials. |
Form : | Lyophilized |
Bio-activity : | Measured by its binding ability in a functional ELISA. Immobilized rhesus TNFRSF9-His at 10 μg/mL (100 μL/well) can bind human TNFSF9, the EC50 of human TNFSF9 is 10-60 ng/mL. |
Molecular Mass : | 18.7 kDa |
N-terminal Sequence Analysis : | Leu 24 |
Endotoxin : | < 1.0 EU/ μg protein as determined by the LAL method. |
Purity : | > (40.7+53.4) % as determined by SDS-PAGE |
Characteristic : | Disulfide-linked homodimer Labeled with Alexa Fluor 647 via amines Excitation = 650 nm Emission = 668 nm |
Storage : | Samples are stable for up to twelve months from date of receipt at -70 centigrade. Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents. |
Gene Name | TNFRSF9 TNF receptor superfamily member 9 [ Macaca mulatta (Rhesus monkey) ] |
Official Symbol | TNFRSF9 |
Synonyms | TNFRSF9; TNF receptor superfamily member 9; tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9 |
Gene ID | 708281 |
mRNA Refseq | NM_001266128 |
Protein Refseq | NP_001253057 |
UniProt ID | F6W5G6 |
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Not For Human Consumption!
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