Active Recombinant Human TNFRSF9, MIgG2a Fc-tagged

• Cat.No.: TNFRSF9-234H
• Product Overview: The extracellular domain of human CD137 (AAH06196.1) (Glu19-Ser184) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO cell.

Specification

• Species: Human
• Source: CHO
• Tag: Fc
• Protein Length: 19-184 a.a.
• Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to theclonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes,enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins havebeen shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its binding ability in a functional ELISA.
• Molecular Mass: 44KDa (monomer)
• AA Sequence: Glu19-Ser184
• Endotoxin: <0.06 eu/μg="" as="" determined="" by="" lal="" test.="">
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: TNFRSF9 tumor necrosis factor receptor superfamily, member 9 [ Homo sapiens ]
• Official Symbol: TNFRSF9
• Synonyms: TNFRSF9; tumor necrosis factor receptor superfamily, member 9; ILA; tumor necrosis factor receptor superfamily member 9; 4 1BB; CD137; CD137 antigen; T cell antigen ILA; T-cell antigen ILA; 4-1BB ligand receptor; homolog of mouse 4-1BB; receptor protein 4-1BB; T-cell antigen 4-1BB homolog; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; 4-1BB; CDw137; MGC2172; FLJ43501
• Gene ID: 3604
• mRNA Refseq: NM_001561
• Protein Refseq: NP_001552
• MIM: 602250
• UniProt ID: Q07011
• Chromosome Location: 1p36
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Downstream signaling in naive CD8+ T cells, organism-specific biosystem
• Function: binding; receptor activity