Active Recombinant Human TXK, GST-tagged
Cat.No. : | TXK-1504H |
Product Overview : | Recombinant human TXK (239-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
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Species : | Human |
Source : | Sf9 Cells |
Tag : | GST |
Protein Length : | 239 aa-end |
Description : | TXK or RLK is a member of the TEC family of non-receptor tyrosine kinases. TXK is expressed in T-cells and is an important component of signaling pathways downstream of lymphocyte antigen receptor.TXK is phosphorylated in response to T-cell receptor stimulation and can be activated by phosphorylation by Src family kinases. However, TXK is phosphorylated independent of PI-3K activity. Excessive TXK protein expression is seen in patients with Behcets disease. Over production of TXK leads to increased Th1 cell function that is involved in the pathogenesis of Behcet?s disease. |
Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | 18 nmol/min/mg |
Molecular Mass : | ~53 kDa |
Purity : | >90% |
Applications : | Kinase Assay, Western Blot |
Storage : | Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles. |
Concentration : | 0.1μg/μl |
Gene Name | TXK TXK tyrosine kinase [ Homo sapiens ] |
Official Symbol | TXK |
Synonyms | TXK; TXK tyrosine kinase; PTK4, PTK4 protein tyrosine kinase 4; tyrosine-protein kinase TXK; BTKL; PSCTK5; RLK; TKL; tyrosine kinase; protein-tyrosine kinase 4; resting lymphocyte kinase; PTK4 protein tyrosine kinase 4; PTK4; MGC22473; |
Gene ID | 7294 |
mRNA Refseq | NM_003328 |
Protein Refseq | NP_003319 |
MIM | 600058 |
UniProt ID | P42681 |
Chromosome Location | 4p12 |
Pathway | Focal Adhesion, organism-specific biosystem; Leukocyte transendothelial migration, organism-specific biosystem; Leukocyte transendothelial migration, conserved biosystem; T Cell Receptor Signaling Pathway, organism-specific biosystem; |
Function | ATP binding; DNA binding; RNA polymerase II regulatory region DNA binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; |
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◆ Cell & Tissue Lysates | ||
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Not For Human Consumption!
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