Active Recombinant Human Tumor Necrosis Factor (Ligand) Superfamily, Member 13b

• Cat.No.: TNFSF13B-352H
• Product Overview: Recombinant human TNFSF13B was expressed in E. coli and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: Human
• Tag: Non
• Description: BAFF Receptor (BAFFR), a member of the TNFR superfamily, is highly expressed in spleen, lymph node, and resting B cells and to some extent in activated B cells, resting CD4+ cells and peripheral blood leukocytes. BAFFR is a type III transmembrane protein that binds with high specificity to BAFF (TNFSF13B). BAFFR/BAFF signaling plays a critical role in B cell survival and maturation.
• Form: Supplied as a lyophilized powder.
• Purity: >95% pure by SDS PAGE and HPLC
• Sequence: Region of BAFF Receptor protein corresponding to amino acids MRRGPRSLRG RDAPAPTPCV PAECFDLLVR HCVACGLLRT PRPKPAGASS PAPRTALQPQ ESVGAGAGEA ALPLPG.
• Molecular Mass: 7.7 kDa
• Applications: Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions
• Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug)
• Bioactivity: Determined by its ability to bl DEG Ck BAFF induced mouse splen DEG Cyte survival. The expected ED50 for this effect is 2.0-4.0 ug/ml in the presence of 1.0ug/ml of human soluble BAFF.
• Storage: Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b [ Homo sapiens ]
• Official Symbol: TNFSF13B
• Synonyms: tumor necrosis factor (ligand) superfamily, member 13b; DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20; TNFSF13B; delta BAFF; B-lymphocyte stimulator; tumor necrosis factor superfamily, member 13b; B-cell activating factor; ApoL related ligand TALL-1; TNF homolog that activates apoptosis; dendritic cell-derived TNF-like molecule; tumor necrosis factor-like protein ZTNF4; TNF and ApoL-related leukocyte expressed ligand 1; tumor necrosis factor (ligand) superfamily, member 20; BLyS; OTTHUMP00000018691; B cell-activating factor; B-lymphocyte stimulator; CD257 antigen; Dendritic cell-derived TNF-like molecule; TNF- and APOL-related leukocyte expressed ligand 1
• Gene ID: 10673
• mRNA Refseq: NM_001145645
• Protein Refseq: NP_001139117
• MIM: 603969
• UniProt ID: Q9Y275
• Chromosome Location: 13q32-q34
• Pathway: Cytokine-cytokine receptor interaction; Intestinal immune network for IgA production; Rheumatoid arthritis
• Function: protein binding; tumor necrosis factor receptor binding; cytokine activity; receptor binding