Active Recombinant Human TNFRSF17 Protein, Fc-tagged, Alexa Fluor 647 conjugated

• Cat.No.: TNFRSF17-121HAF647
• Product Overview: The Alexa Fluor 647 conjugated extracellular domain of human BCMA (aa 2-54) is fused at the C-terminus to the Fc portion of human IgG1.

Specification

• Description: BCMA is a receptor for BAFF and APRIL. It promotes B cell survival and plays a role in the regulation of humoral immunity. Its downstream signaling is dependent on NF-kappa; B and JNK.
• Source: HEK293
• Species: Human
• Tag: Fc
• Form: Lyophilized
• Bio-activity: Blocks the binding of BAFF and APRIL to their receptors BCMA and TACI, inhibiting BAFF- and APRIL-mediated B cell activation.
• Molecular Mass: ~40 kDa (SDS-PAGE)
• Purity: ≥95 % by SDS-PAGE
• Characteristic: Disulfide-linked homodimer
  Labeled with Alexa Fluor 647 via amines
  Excitation = 650 nm
  Emission = 668 nm
• Stability: Stable for at least 6 months after receipt when stored at -20 centigrade.
• Storage: Short Term Storage: +4 centigrade; Long Term Storage: -20 centigrade. After reconstitution, prepare aliquots and store at -20 centigrade. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.
• Concentration: 1 mg/mL
• Storage Buffer: Contains PBS.
• Protein length: 2-54 a.a.

Gene Information

• Gene Name: TNFRSF17 tumor necrosis factor receptor superfamily, member 17 [ Homo sapiens ]
• Official Symbol: TNFRSF17
• Synonyms: TNFRSF17; tumor necrosis factor receptor superfamily, member 17; BCMA; tumor necrosis factor receptor superfamily member 17; BCM; CD269; B-cell maturation factor; B cell maturation antigen; B-cell maturation protein
• Gene ID: 608
• mRNA Refseq: NM_001192
• Protein Refseq: NP_001183
• MIM: 109545
• UniProt ID: Q02223