Recombinant Human TNFRSF17

• Cat.No.: TNFRSF17-2604H
• Product Overview: Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 17 produced inE.Coliis a single, non-glycosylated, polypeptide chain containing 50 amino acids and having a molecular mass of 5.3 kDa. The TNFRSF17 is purified by standard chromatographic techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: TNFRSF17 is a receptor for tnfsf13b/blys/baff and tnfsf13/april. TNFRSF17 promotes b-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 activates nf-kappa-b and jnk. TNFRSF17 is a member of the TNF-receptor superfamily. TNFRSF17 is expressed in mature B lymphocytes, and is invloved in B cell development and autoimmune response. TNFRSF17 specifically binds to the tumor TNFSF13B/TALL-1/BAFF, which causes NF-kappaB and MAPK8/JNK activation. TNFRSF17 binds to a variety of TRAF family members, and therefore transduces signals for cell survival and proliferation. TNFRSF17 is a type III membrane protein having 1 extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI.
• Purity: Greater than 98% as determined by SDS-PAGE.
• Sequence: AGQCSQNEYF DSLLHACIPC QLRCSSNTPP LTCQRYCNAS VTNSVKGTNA.
• Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
• Formulation: 1mg of TNFRSF17 Human contains 20mM PBS, pH-7.4, and 130mM NaCl.
• Solubility: It is recommended to reconstitute the lyophilized TNFRSF17 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
• Storage: Lyophilized TNFRSF17 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TNFRSF17 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze/thaw cycles.

Gene Information

• Gene Name: TNFRSF17 tumor necrosis factor receptor superfamily, member 17 [ Homo sapiens ]
• Synonyms: TNFRSF17; tumor necrosis factor receptor superfamily, member 17; BCM; BCMA; CD269; TNFRSF17; tumor necrosis factor receptor superfamily member 17; B-cell maturation factor; B-cell maturation protein
• Gene ID: 608
• mRNA Refseq: NM_001192
• Protein Refseq: NP_001183
• MIM: 109545
• UniProt ID: Q02223
• Chromosome Location: 16p13.1
• Pathway: Cytokine-cytokine receptor interaction; Intestinal immune network for IgA production
• Function: protein binding; receptor activity; tumor necrosis factor receptor activity

Citation

Directed evolution of adenine base editors with increased activity and therapeutic application.

Journal: Nature biotechnology    PubMed ID: 32284586    Data: 2020/10/7

Authors: Nicole M Gaudelli, Dieter K Lam, Giuseppe Ciaramella

Article Snippet:Specific details are listed below for each antibody.. Cbl-b: https://www.cellsignal.com/products/primary-antibodies/cbl-b-d3c12-rabbit-mab/9498 Western blot showing binding to human Cblb from various human cell line lysates CD3: https://www.biolegend.com/en-us/products/pe-anti-human-cd3-antibody-865 Product insert shows staining of human lymphocytes with CD3-PE versus isotype control CD7: https://www.biolegend.com/en-us/products/fitc-anti-human-cd7-antibody-6009 Product insert shows staining of human lymphocytes with CD7-FITC versus isotype control HLA-DR: https://www.biolegend.com/en-us/products/pe-anti-human-hla-dr-antibody-790 Product insert shows staining of human lymphocytes with HLADR-PE versus isotype control B2M: https://www.biolegend.com/en-us/products/pe-anti-human-beta2-microglobulin-antibody-3080 Product insert shows staining of human lymphocytes with B2M-PE versus isotype control CD279: https://www.thermofisher.com/antibody/product/CD279-PD-1-Antibody-clone-eBioJ105-J105-Monoclonal/12-2799-42 Data gallery showing unstimuated human peripheral blood cells versus PHA stimulated human peripheral blood cells stained with CD279-PE TNFRSF17: https://www.creativebiomart.net/recombinant-human-tnfrsf17-protein-fc-tagged-468989.htm Human TNFRSF17 produced by HEK293 cells and comfired via Coomassie Blue staining post SDS-PAGE 3 nature research | reporting sum m ary O ctober 2018 Eukaryotic cell lines Policy information about cell lines Cell line source(s) Hek293T: American Type Cell Culture Collection (ATCC) Authentication Done by supplier Mycoplasma contamination Tested negative for mycoplasma contamination by the supplier, ATCC.. Commonly misidentified lines (See ICLAC register) The cell line used is not listed as commonly misidentified.