Active Recombinant Human TIMP2, HIgG1 Fc-tagged

• Cat.No.: TIMP2-002H
• Product Overview: The extracellular domain of human TIMP2(AAH52605.1)(Cys27-Pro220) is fused to the N-terminus of the Fc region of human IgG1 was expressed in CHO cell.

Specification

• Description: This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors ofthe matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. Inaddition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMPfamily members in its ability to directly suppress the proliferation of endothelial cells. As a result, theencoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation ofquiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoingremodelling of the extracellular matrix.
• Source: CHO cell
• Species: Human
• Tag: HIgG1 Fc-tagged
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its ability to induce alkaline phosphatase production .
• Molecular Mass: 48KDa (monomer)
• AA Sequence: Cys27-Pro220
• Endotoxin: <0.06 eu/μg as determined by lal test.>
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.
• Protein length: Cys27-Pro220

Gene Information

• Gene Name: TIMP2 TIMP metallopeptidase inhibitor 2 [ Homo sapiens ]
• Official Symbol: TIMP2
• Synonyms: TIMP2; TIMP metallopeptidase inhibitor 2; tissue inhibitor of metalloproteinase 2; metalloproteinase inhibitor 2; CSC 21K; TIMP-2; tissue inhibitor of metalloproteinases 2; CSC-21K
• Gene ID: 7077
• mRNA Refseq: NM_003255
• Protein Refseq: NP_003246
• MIM: 188825
• UniProt ID: P16035
• Chromosome Location: 17q25
• Pathway: Activation of Matrix Metalloproteinases, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem; Matrix Metalloproteinases, organism-specific biosystem
• Function: enzyme activator activity; enzyme inhibitor activity; integrin binding; metal ion binding; metalloendopeptidase inhibitor activity