Active Recombinant Human TGFB1, MIgG2a Fc-tagged

• Cat.No.: TGFB1-219H
• Product Overview: The extracellular domain of a mutant human TGFβ1 is fused to the N-terminus of the Fc region of mouseIgG2a. Site-directed mutagenesis was used to change three cysteine codons into a serine codon that are located in the pro region of the TGF-β precursor at

Specification

• Description: This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which aremultifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functionsin many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates manyother growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latentTGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also formheterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations inthis gene result in Camurati-Engelmann disease
• Source: CHO cell
• Species: Human
• Tag: MIgG2a Fc-tagged
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Acts in conjunction with rapamycin to inhibit T cell proliferation and induce the denovo generation of Foxp3+ Treg in the periphery, and inhibiting IL6-mediated Th17 cell differentiation.
• Molecular Mass: 70 KDa (monomer)
• AA Sequence: The extracellular domain of a mutant human TGFβ1 is fused to the N-terminus of the Fc region of mouseIgG2a. Site-directed mutagenesis was used to change three cysteine codons into a serine codon that are located in the pro region of the TGF-β precursor at
• Endotoxin: <0.06 eu/μg="" as="" determined="" by="" lal="" test.="">
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: TGFB1 transforming growth factor, beta 1 [ Homo sapiens ]
• Official Symbol: TGFB1
• Synonyms: TGFB1; transforming growth factor, beta 1; DPD1, TGFB; transforming growth factor beta-1; Camurati Engelmann disease; CED; TGFbeta; TGF-beta-1; TGF-beta 1 protein; latency-associated peptide; LAP; DPD1; TGFB
• Gene ID: 7040
• mRNA Refseq: NM_000660
• Protein Refseq: NP_000651
• MIM: 190180
• UniProt ID: P01137
• Chromosome Location: 19q13.1
• Pathway: ACE Inhibitor Pathway, organism-specific biosystem; ALK1 signaling events, organism-specific biosystem; Adipogenesis, organism-specific biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem
• Function: enzyme binding; eukaryotic cell surface binding; growth factor activity; protein N-terminus binding; protein binding; protein heterodimerization activity; protein homodimerization activity; type II transforming growth factor beta receptor binding; type II