Active Recombinant Human TESK2, GST-tagged

• Cat.No.: TESK2-252H
• Product Overview: Recombinant full-length human TESK2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: TESK2 or testis-specific kinase 2 is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. The kinase domain of TESK2 is structurally similar to the kinase domain of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). TESK2 is predominantly expressed in testis and prostate and plays an important role in spermatogenesis. TESK2 phosphorylates cofilin specifically at Ser-3 and induces formation of actin stress fibers and focal adhesions.
• Form: Recombinant protein stored in 50mM Tis-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Bio-activity: The specific activity of TESK2 was determined to be 3.5 nmol /min/mg
• Molecular Mass: ~92 kDa
• Purity: >80% by densitometry
• Applications: Kinase Assay, Western Blot
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 μg/μl

Gene Information

• Gene Name: TESK2 testis-specific kinase 2 [ Homo sapiens ]
• Official Symbol: TESK2
• Synonyms: TESK2; testis-specific kinase 2; dual specificity testis-specific protein kinase 2; testicular protein kinase 2
• Gene ID: 10420
• mRNA Refseq: NM_007170
• Protein Refseq: NP_009101
• MIM: 604746
• UniProt ID: Q96S53
• Chromosome Location: 1p32
• Pathway: Focal Adhesion, organism-specific biosystem
• Function: ATP binding; metal ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity