TESK2
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Official Full Name
testis-specific kinase 2 -
Overview
This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. -
Synonyms
TESK2;testis-specific kinase 2;dual specificity testis-specific protein kinase 2;testicular protein kinase 2
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Mouse
- E.coli
- Sf9 Cells
- Mammalian Cells
- HEK293
- His
- GST
- Non
- Avi&Fc&His
- DDK&Myc
Involved Pathway
TESK2 involved in several pathways and played different roles in them. We selected most pathways TESK2 participated on our site, such as Focal Adhesion,Regulation of Microtubule Cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with TESK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Focal adhesion | VAV3B,MYL10,PDGFAB,ITGA6,RAP1AB,ITGAV,RAC3,RAPGEF1,PPP1CB,CAV1 |
| Regulation of Microtubule Cytoskeleton | MAP1B,MARK2,TPPP,MARK1,DPYSL2,CFL2 |
Protein Function
TESK2 has several biochemical functions, for example, ATP binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TESK2 itself. We selected most functions TESK2 had, and list some proteins which have the same functions with TESK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine/tyrosine kinase activity | DYRK1B,ACVR2B,DYRK1AA,TESK1,AURKA,RPS6KA1,SGK1,DSTYK,CLK3,RPS6KA2 |
| protein serine/threonine kinase activity | TBK1,GRK7A,PAK1,MAP3K10,LMTK2,PIK3R4,STK16,TNNI3K,PRKCQ,NUAK2 |
| protein tyrosine kinase activity | CAMKK2,EPHB2B,MET,EPHB4A,INSR,Fert2,CSK,NTRK3A,PTK7,MAP2K1 |
| protein binding | MYPOP,SMYD2,WFDC9,NAE1,C19orf44,SEMA7A,ZNF830,FARSA,FGF2,FLAD1 |
| metal ion binding | GNAT1,TMPPE,ECE2,ZNF697,TDP2B,TH2,DEAF1,COL27A1,C6AST4,AOX4 |
| ATP binding | IQCA1,DDX56,DSTYK,SLC22A5,ATP13A,PRKCQ,SRMS,IGF1RB,VMHCL,LONP1 |
| protein kinase activity | CAMK2B1,PTK2AA,TGFBR1A,EGFRA,GC2,SGK2B,ARAF,PRKCDA,NPR1,VRK1 |
Interacting Protein
TESK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TESK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TESK2.
HSP90AB1;linkable pd173955 analogue;bosutinib
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References
- Motiei, M; Tavalaee, M; et al. Evaluation of HSPA2 in fertile and infertile individuals. ANDROLOGIA 45:66-72(2013).
- Jha, KN; Coleman, AR; et al. Heat Shock Protein 90 Functions to Stabilize and Activate the Testis-specific Serine/Threonine Kinases, a Family of Kinases Essential for Male Fertility. JOURNAL OF BIOLOGICAL CHEMISTRY 288:16308-16320(2013).
