Active Recombinant Human RBBP5 Protein

• Cat.No.: RBBP5-082H
• Product Overview: Recombinant human RBBP5 protein without tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Description: This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
• Bio-activity: Activity was demonstrated by a radiometric assay of the MLL1/WAR complex (Ash2L, WDR5, RbBP5 and MLL1) and MLL1/WARD complex (Ash2L, WDR5, RbBP5, MLL1, and DPY-30) using [3H]-S-adenosylmethionine and Core Histones which specifically methylates Histone H3.
• Molecular Mass: 72.9 kDa
• Purity: ≥90%
• Stability: ≥ 1 year
• Storage: At -80 centigrade.
• Storage Buffer: 50 mM Tris, pH 8.0, containing 150 mM sodium chloride and 20% glycerol

Gene Information

• Gene Name: RBBP5 RB binding protein 5, histone lysine methyltransferase complex subunit [ Homo sapiens (human) ]
• Official Symbol: RBBP5
• Synonyms: RBBP5; RB binding protein 5, histone lysine methyltransferase complex subunit; RBQ3; SWD1; retinoblastoma-binding protein 5; RBBP-5; SWD1, Set1c WD40 repeat protein, homolog; retinoblastoma-binding protein RBQ-3
• Gene ID: 5929
• mRNA Refseq: NM_005057
• Protein Refseq: NP_005048
• MIM: 600697
• UniProt ID: Q15291