Active Recombinant Human PTPRA, GST-tagged

• Cat.No.: PTPRA-1521H
• Product Overview: Recombinant human PTPRA (174-802) was expressed in E. coli cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 174-802 aa
• Description: PTPRA (also known as LRP) is a member of the protein tyrosine phosphatase family and contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. PTPRA dephosphorylates SRC family kinases, potassium channels and NMDA receptors and exists as three alternatively spliced variants which encode two distinct isoforms. Absence of PTPRA compromises correct positioning of pyramidal neurons during development of mouse hippocampus.
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 2117 nmol/min/mg
• Molecular Mass: ~96 kDa
• Purity: >90%
• Applications: Phosphatase Assay, Western Blot
• Storage: Store at–70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: PTPRA protein tyrosine phosphatase, receptor type, A [ Homo sapiens ]
• Official Symbol: PTPRA
• Synonyms: PTPRA; protein tyrosine phosphatase, receptor type, A; PTPA, PTPRL2; receptor-type tyrosine-protein phosphatase alpha; HLPR; HPTPA; LRP; RPTPA; PTPase-alpha; PTPLCA-related phosphatase; tyrosine phosphatase alpha; protein-tyrosine phosphatase alpha; protein tyrosine phosphatase, receptor type, alpha polypeptide; Leukocyte common antigen-related peptide (protein tyrosine phosphate); PTPA; HEPTP; PTPRL2; HPTPalpha; R-PTP-alpha
• Gene ID: 5786
• mRNA Refseq: NM_002836
• Protein Refseq: NP_002827
• MIM: 176884
• UniProt ID: P18433
• Chromosome Location: 20p13
• Pathway: Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Insulin Pathway, organism-specific biosystem; NCAM signaling for neurite out-growth, organism-specific biosystem
• Function: hydrolase activity; protein tyrosine phosphatase activity; receptor activity; transmembrane receptor protein tyrosine phosphatase activity