PTPRA
-
Official Full Name
protein tyrosine phosphatase, receptor type, A -
Overview
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. -
Synonyms
PTPRA;protein tyrosine phosphatase, receptor type, A;PTPA, PTPRL2;receptor-type tyrosine-protein phosphatase alpha;HLPR;HPTPA;LRP;RPTPA;PTPase-alpha;PTPLCA-related phosphatase;tyrosine phosphatase alpha;protein-tyrosine phosphatase alpha;prote
Recombinant Proteins
- Human
- Chicken
- Rat
- Zebrafish
- Mouse
- E.coli
- Sf9 Cells
- Mammalian Cells
- Insect Cells
- HEK293
- GST
- His
- His&GST
- His&T7
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
PTPRA involved in several pathways and played different roles in them. We selected most pathways PTPRA participated on our site, such as ARMS-mediated activation,Axon guidance,Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPRA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DAP12 interactions | AGO2,MARK3,FGF10B,SPTA1,SPTBN2,PAQR3A,RASGEF1A,CNKSR1,WDR83,FGF20A |
| DAP12 signaling | SPRED3,PAQR3A,SPTB,PEA15A,SPRED2,DAB2IPB,CNKSR1,PRKAR1AA,FRS3,FGF18B |
| ARMS-mediated activation | RASGRP4,DUSP1,DUSP6,KLB,RASGRP1,CNKSR1,CRK,JAK3,DLG4,CSF2RA |
| Axon guidance | AGRN,CXCL12,CSK,PHB,PTK2,CDK5R1B,MYL9,SEMA3C,CHL1,JAK3 |
| Downstream signaling of activated FGFR1 | IL17RD,DUSP9,SPTA1,PEA15A,DUSP2,AGO2,WDR83,RASGEF1A,SPTB,SPRED3 |
| Downstream signal transduction | FGF10B,WDR83,SPTBN1,DAB2IPB,FRS3,FGF20A,SPTB,PAQR3B,THEM4,AGO1 |
| Developmental Biology | EPHB3A,JAK1,EFNA2,ST8SIA2,COL6A2,DPYSL5B,ARPC5,MED20,EFNA1A,GPC1A |
| Cytokine Signaling in Immune system | IFIT3,IFI27,IRF2,GBP4,DUSP6,KPNA4,FGF20A,NEFLB,TRIM45,CSH1 |
Protein Function
PTPRA has several biochemical functions, for example, protein binding,protein tyrosine phosphatase activity,transmembrane receptor protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPRA itself. We selected most functions PTPRA had, and list some proteins which have the same functions with PTPRA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | NUDT1,LILRA4,CERK,CRYGC,PYGL,TMEM123,LDB1,C10orf35,ZFPL1,APPL1 |
| protein tyrosine phosphatase activity | PTPRJA,MDP1,PTPRG,CDC25A,PTPRU,CDC14A,PTPRDB,PTPN22,PTPRC,MTMR7 |
| transmembrane receptor protein tyrosine phosphatase activity | EVLA,PTPRF,PTPRS,PTPRG,PTPRO,PTPRN2,PTPRUB,PTPRB,PTPRE,PTPRC |
Interacting Protein
PTPRA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPRA here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPRA.
GRB2;SRC;SRC;Fyn;UVRAG
Resources
Related Services
Related Products
References
