Active Recombinant Human PIP4K2A protein, GST-tagged

• Cat.No.: PIP4K2A-167H
• Product Overview: Recombinant Human PIP4K2A fused with an N-terminal GST tag was expressed in Insect cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Description: PIP4K2A or phosphatidylinositol-5-phosphate 4-kinase, type II, alpha, is a member of the phosphatidylinositol-5-phosphate 4-kinase family that catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate. PIP4K2A plays as essential role in the phosphoinositide signal transduction cascades as the precursor to second messengers and is involved in the regulation of secretion, cell proliferation, differentiation, and motility. PIP4K2A may be one of the factors related to the regulation of the beta-globin gene expression and the different levels of Hb H in alpha-thalassemic patients.
• Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 13250 nmol/min/mg
• Molecular Mass: 76 kDa
• Purity: >95%
• Applications: Kinase Assay
• Stability: 1 year at -70 centigrade from the date of shipment
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha [ Homo sapiens ]
• Official Symbol: PIP4K2A
• Synonyms: PIP4K2A; phosphatidylinositol-5-phosphate 4-kinase, type II, alpha; phosphatidylinositol 4 phosphate 5 kinase, type II, alpha , PIP5K2A; phosphatidylinositol-5-phosphate 4-kinase type-2 alpha; PIP5KIIA; PIP5KIIalpha; PIP5KIII; PIP4KII-alpha; PI(5)P 4-kinase type II alpha; PtdIns(4)P-5-kinase B isoform; ptdIns(4)P-5-kinase C isoform; diphosphoinositide kinase 2-alpha; ptdIns(5)P-4-kinase isoform 2-alpha; 1-phosphatidylinositol-4-phosphate kinase; 1-phosphatidylinositol-4-phosphate-5-kinase; 1-phosphatidylinositol-5-phosphate 4-kinase 2-alpha; phosphatidylinositol-4-phosphate 5-kinase, type II, alpha; type II phosphatidylinositol-4-phosphate 5-kinase 53 K isoform; PIPK; PI5P4KA; PIP5K2A; FLJ13267; PIP5KII-alpha
• Gene ID: 5305
• mRNA Refseq: NM_005028
• Protein Refseq: NP_005019
• MIM: 603140
• UniProt ID: P48426
• Chromosome Location: 10p12.2
• Pathway: B Cell Receptor Signaling Pathway, organism-specific biosystem; D-myo-inositol (1,4,5)-trisphosphate biosynthesis, organism-specific biosystem; D-myo-inositol-5-phosphate metabolism, organism-specific biosystem; G13 Signaling Pathway, organism-specific biosystem; Inositol phosphate metabolism, organism-specific biosystem; Inositol phosphate metabolism, conserved biosystem; Phosphatidylinositol signaling system, organism-specific biosystem
• Function: 1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; ATP binding; nucleotide binding; transferase activity