Active Recombinant Human PIM2, GST-tagged

• Cat.No.: PIM2-1456H
• Product Overview: Recombinant full-length human PIM2 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: Full length
• Description: PIM2 is a serine threonine kinase that is present in all tissues, being most abundant in hematopoietic tissues, spleen, thymus, and peripheral blood leukocytes, as well as in testis, small intestine, and colon. It is highly expressed in human leukemic, lymphoma and colorectal adenocarcinoma cell lines. This suggests a role for PIM2 in proliferating cells as well as during meiosis. Similar to PIM1, PIM2 also acts as a pro-survival kinase and BAD protein is a legitimate PIM2 substrate.
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 305 nmol/min/mg
• Molecular Mass: ~61 kDa
• Purity: >95%
• Applications: Kinase Assay, Western Blot
• Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: PIM2 pim-2 oncogene [ Homo sapiens ]
• Official Symbol: PIM2
• Synonyms: PIM2; pim-2 oncogene; serine/threonine-protein kinase pim-2; pim-2h; serine/threonine protein kinase pim-2; proto-oncogene Pim-2 (serine threonine kinase)
• Gene ID: 11040
• mRNA Refseq: NM_006875
• Protein Refseq: NP_006866
• MIM: 300295
• UniProt ID: Q9P1W9
• Chromosome Location: Xp11.23
• Pathway: Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem
• Function: ATP binding; nucleotide binding; protein serine/threonine kinase activity