Active Recombinant Human PIK3CG protein, His-tagged

• Cat.No.: PIK3CG-158H
• Product Overview: Recombinant Human PIK3CG fused with an N-terminal His tag was expressed in Insect cells.

Specification

• Description: PI3K (p120 gamma) is a member of the PI3K family that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. PI3K (p120 gamma) is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, PI3K (p120 gamma) is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. In addition, PI3K (p120 gamma) plays an inhibitory role in inflammatory mediator-induced human vascular smooth muscle cell calcification through regulating alkaline phosphatase expression.
• Source: Insect cells
• Species: Human
• Tag: His
• Form: 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
• Bio-activity: 230 nmol/min/mg
• Molecular Mass: 121 kDa
• Purity: >95%
• Applications: Kinase Assay
• Stability: 1 year at -70 centigrade from the date of shipment
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide [ Homo sapiens ]
• Official Symbol: PIK3CG
• Synonyms: PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; p110gamma; p120-PI3K; PI3K-gamma; p110-gamma; PI3-kinase subunit gamma; ptdIns-3-kinase subunit gamma; 1-phosphatidylinositol 3-kinase; ptdIns-3-kinase subunit p110-gamma; serine/threonine protein kinase PIK3CG; phosphatidylinositol 3 kinase gamma, p110 gamma; phosphoinositide-3-kinase gamma catalytic subunit; phosphatidylinositol 3-kinase catalytic 110-kD gamma; phosphatidylinositol 3-kinase, catalytic, gamma polypeptide; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; PI3K; PIK3; PI3CG; PI3Kgamma
• Gene ID: 5294
• mRNA Refseq: NM_002649
• Protein Refseq: NP_002640
• MIM: 601232
• UniProt ID: P48736
• Chromosome Location: 7q22
• Pathway: 3-phosphoinositide biosynthesis, organism-specific biosystem; 3-phosphoinositide biosynthesis, conserved biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem
• Function: 1-phosphatidylinositol-3-kinase activity; ATP binding; binding; ephrin receptor binding; nucleotide binding; phosphatidylinositol 3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein kinase activity; protein serine/threonine kinase activity