Active Recombinant Human PDCD1 Protein

• Cat.No.: PDCD1-01H
• Product Overview: Recombinant Human PDCD1 Protein was expressed in HEK293 cell

Specification

• Description: Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity.
• Source: HEK293
• Species: Human
• Form: Lyophilized
• Bio-activity: Measured by its binding ability in a functional ELISA.
• Molecular Mass: Expected molecular weight ~16 kD, observed molecular weight 30 kD in SDS-PAGE due to glycosylation of the protein.
• Protein length: Protein fragment
• AA Sequence: LDSPDRPWNP PTFSPALLVV TEGDNATFTC SFSNTSESFV LNWYRMSPSN QTDKLAAFPE DRSQPGQDCR FRVTQLPNGR DFHMSVVRAR RNDSGTYLCG AISLAPKAQI KESLRAELRV TERRAEVPTA HPSPSPRPAG QFQ
• Endotoxin: < 0.010 Eu/µg
• Purity: > 95 % SDS-PAGE.
• Applications: SDS-PAGE
  Functional Studies
• Notes: FOR RESEARCH USE ONLY.NOT FOR USE IN DIAGNOSTIC PROCEDURES
• Storage: Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
  Constituent: PBS
  Lyophilized from 0.2µm-filtered solution.
  This product is an active protein and may elicit a biological response in vivo, handle with caution.
• Storage Buffer: Lyophilized from 0.2µm-filtered solution.
• Reconstitution: Reconstitute 50µg vial with 100 µl sterile water to a concentration of 0.5 mg/ml. Add 1X PBS to the desired protein concentration. PBS containing at least 0.1% BSA should be used for further dilutions.
• Shipping: Shipped at 4°C.

Gene Information

• Gene Name: PDCD1 programmed cell death 1 [ Homo sapiens (human) ]
• Official Symbol: PDCD1
• Synonyms: PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1
• Gene ID: 5133
• mRNA Refseq: NM_005018.3
• Protein Refseq: NP_005009.2
• MIM: 600244
• UniProt ID: Q15116