Active Recombinant Human PARP1 Protein, MYC/His-Tagged

• Cat.No.: PARP1-03H
• Product Overview: Recombinant Human PARP1 Protein, MYC/His-Tagged was expressed in Sf21 insect cells.

Specification

• Species: Human
• Source: Sf21 Cells
• Description: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
• Form: Liquid
• Bio-activity: ≥1’200U/mg protein.
• Purity: ≥98% (SDS-PAGE)
• Usage: RUO - Research Use Only
• Storage: long time storage: -80°C
• Storage Buffer: Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 50mM imidazole, 0.2% NP-40 and 10% glycerol.
• Handling: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
• Shipping: Shipped on Dry Ice

Gene Information

• Gene Name: PARP1 poly(ADP-ribose) polymerase 1 [ Homo sapiens (human) ]
• Official Symbol: PARP1
• Synonyms: PARP; PARS; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1; Poly-PARP
• Gene ID: 142
• mRNA Refseq: NM_001618.3
• Protein Refseq: NP_001609.2
• MIM: 173870
• UniProt ID: P09874