PARP1
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Official Full Name
poly (ADP-ribose) polymerase 1 -
Overview
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008] -
Synonyms
PARP1;poly (ADP-ribose) polymerase 1;PARP;PPOL;ADPRT;ARTD1;ADPRT1;PARP-1;ADPRT 1;pADPRT-1;poly [ADP-ribose] polymerase 1;poly(ADP-ribose) polymerase;poly(ADP-ribose) synthetase;poly[ADP-ribose] synthase 1;poly(ADP-ribosyl)transferase;ADP-ribosyltransferase NAD(+);NAD(+) ADP-ribosyltransferase 1;poly (ADP-ribose) polymerase family, member 1;ADP-ribosyltransferase diphtheria toxin-like 1;ADP-ribosyltransferase (NAD+;poly (ADP-ribose) polymerase)
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- Chicken
- E.coli
- Insect Cells
- Sf21 Cells
- Sf9 Cells
- Mammalian Cells
- HEK293
- His
- Myc
- HA
- Non
- Flag
- GST
- DDK&Myc
- Avi&Fc&His
- Avi&Flag
- GST&His
Involved Pathway
PARP1 involved in several pathways and played different roles in them. We selected most pathways PARP1 participated on our site, such as Base Excision Repair,Caspase cascade in apoptosis,Corticotropin-releasing hormone, which may be useful for your reference. Also, other proteins which involved in the same pathway with PARP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Corticotropin-releasing hormone | TCF4,CYP11A1,CRHR1,KRT1,IVL,TBX19,CRH,JUND,KRT14,TFAP2A |
| Base excision repair | TDG,PCNA,PARP4,NEIL2,SMUG1,LIG1,MUTYH,HMGB1B,TDG.1,NEIL3 |
| DNA Repair | MGMT,UBE2L6,ASCC3,KIAA0146,BRCC3,EYA2,POLD3,USP45,RNF168,PPP4R2B |
| DNA Double-Strand Break Repair | BRCC3,CHEK2,RAD51AP1,TP53BP1,TOPBP1,RNF168,TDP2,PPP4CA,DNA2,WRN |
| DNA Damage Recognition in GG-NER | TFPT,COPS8,INO80B,INO80E,CETN2,NFRKB,YY1A,COPS7A,COPS2,DDB2 |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | SKILB,SKI,SKIA,TRIM33,SMAD3B,SKIB,USP9X,RNF111,USP9 |
| Caspase cascade in apoptosis | NUMA1,DIABLO,TFAP2A,CASP2,GAS2,CASP4,TOP1,DFFA,ACTA1,CFL2 |
Protein Function
PARP1 has several biochemical functions, for example, DNA binding,NAD binding,NAD+ ADP-ribosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PARP1 itself. We selected most functions PARP1 had, and list some proteins which have the same functions with PARP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NAD+ ADP-ribosyltransferase activity | GIG2O,PARP6,GIG2E,CHAT1,SIRT6,TNKS2,GIG2I,ART3,TIPARP,ZC3HAV1 |
| transcription factor binding | NKX3-1,E2F4,CEBPG,IRF4,PPARGC1A,HES4,DIP2B,PARD6A,NKX2,PELP1 |
| NAD binding | MDH1,GPD1C,HIBADH,ME1,CTBP1,DLD,IDH3A,HSD3B5,GRHPR,GAPDH |
| chromatin binding | MCMBP,ATF2,TADA2B,PKN1,SIRT2,ATOH1A,SOX15,ORC1L,NR5A2,YBX1 |
| protein N-terminus binding | NFE2,THAP7,RPA3,ZWINT,KCNIP1,NCOR2,ATM,EIF5A,SLA2,MAU2 |
| identical protein binding | CCDC155,STIM1,ERN1,KRTAP10-5,PACSIN2,MCM10,TTR,PKD2L1,L3MBTL1,GRB7 |
| enzyme binding | DDX5,SCNM1,LUC7L2,CSF3,ATP2A2,UGT1A4,ARPC4,PLAUR,ZFHX3,KMT2E |
| DNA binding | YEATS4,HOXB6A,HER6,NKX1.2LB,OLIG1,ILF3B,TFCP2,ZEB2,TIGD5,TCF4 |
| zinc ion binding | ZNF75D,HE1A,DPF2,TRIM15,TET1,GCH1,RNF25,MT1M,PHEX,WTIP |
Interacting Protein
PARP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PARP1.
XRCC5;TP53;WRN
Resources
Research Area
Cancer Drug TargetsADP-ribosyltransferases (ARTs)
Diabetic Peripheral Neuropathy
Asthma Therapeutic Targets
Autoimmune Disease Therapeutic Targets
Breast Cancer Biomarkers
Related Services
Related Products
References
- Beck, C; Robert, I; et al. Poly(ADP-ribose) polymerases in double-strand break repair: Focus on PARP1, PARP2 and PARP3. EXPERIMENTAL CELL RESEARCH 329:18-25(2014).
- Kim, J; Lim, W; et al. Photodynamic therapy (PDT) resistance by PARP1 regulation on PDT-induced apoptosis with autophagy in head and neck cancer cells. JOURNAL OF ORAL PATHOLOGY & MEDICINE 43:675-684(2014).
