Active Recombinant Human NUAK1, GST-tagged
| Cat.No. : | NUAK1-1067H |
| Product Overview : | Recombinant full-length human NUAK1 (ARK5) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
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| Description : | NUAK1 or SNF1/AMP kinase-related kinase (SNARK) is a member of the NUAK family of SNF1-like kinase 1 that is also known as AMPK-related protein kinase 5 (ARK5). ARK5 is a tumor cell survival factor that is activated by AKT and acts as an ATM kinase under conditions of nutrient starvation. NUAK1 is highly expressed in heart and brain, and at lower levels in skeletal muscle, kidney, ovary, placenta, lung, and liver. NUAK1 is involved in tolerance to glucose starvation and suppresses Fas-induced apoptosis by phosphorylation of CASP6, thus suppressing the activation of the caspase and the subsequent cleavage of CFLAR. |
| Source : | Sf9 insect cells |
| Species : | Human |
| Tag : | GST |
| Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Bio-activity : | 50 nmol/min/mg |
| Molecular Mass : | ~122 kDa |
| Protein length : | Full Length |
| Purity : | >80% |
| Applications : | Kinase Assay; Western Blot |
| Stability : | 1 yr at -70oC from date of shipment. |
| Storage : | Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Concentration : | 0.1 ug/ul |
| Gene Name | NUAK1 NUAK family, SNF1-like kinase, 1 [ Homo sapiens ] |
| Official Symbol | NUAK1 |
| Synonyms | NUAK1; NUAK family, SNF1-like kinase, 1; AMP-activated protein kinase family member 5; AMPK-related protein kinase 5; NUAK family SNF1-like kinase 1; ARK5; KIAA0537; EC 2.7.11.1 |
| Gene ID | 9891 |
| mRNA Refseq | NM_014840 |
| Protein Refseq | NP_055655 |
| MIM | 608130 |
| UniProt ID | O60285 |
| Chromosome Location | 12q23.3 |
| Function | ATP binding; metal ion binding; protein binding; protein serine/threonine kinase activity |
Not For Human Consumption!
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