Active Recombinant Human NRG4 Protein
Cat.No. : | NRG4-07H |
Product Overview : | Recombinant Human Neuregulin-4 EGF domain was expressed in Escherichia coli. |
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Species : | Human |
Source : | E.coli |
Description : | The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation. |
Form : | Lyophilized |
Bio-activity : | The ED(50) was determined by the phosphorylation of ErbB2 and ErbB4 receptors in CHO cells, and was found to be < 3 ng/mL, corresponding to a specific activity of × Units/mg. |
Molecular Mass : | Recombinant human Neuregulin-4 EGF domain is a monomeric protein consisting of 62 amino acid residue subunits, and migrates as an approximately 7 kDa protein under non-reducing and reducing conditions in SDS-PAGE. |
AA Sequence : | MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSNLFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSHEQH |
Endotoxin : | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 1 ng/μg (1 EU/μg). |
Purity : | >96%, as determined by SDS-PAGE and HPLC |
Usage : | This cytokine product is for research purposes only. It may not be used for therapeutics or diagnostic purposes. |
Storage : | The lyophilized protein is stable for at least years from date of receipt at -20 centigrade. Upon reconstitution, this cytokine can be stored in working aliquots at -20 centigrade for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
Storage Buffer : | Recombinant Neuregulin-4 was lyophilized from 0.2 μm filtered PB, pH7.0. |
Reconstitution : | A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 1 mg/mL. This solution can then be diluted into other buffers. |
Gene Name | NRG4 neuregulin 4 [ Homo sapiens (human) ] |
Official Symbol | NRG4 |
Synonyms | NRG4; neuregulin 4; HRG4; pro-neuregulin-4, membrane-bound isoform; heregulin 4; pro-NRG4 |
Gene ID | 145957 |
mRNA Refseq | NM_138573 |
Protein Refseq | NP_612640 |
MIM | 610894 |
UniProt ID | Q8WWG1 |
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NRG4-333H | Recombinant Human NRG4 protein, His-tagged | +Inquiry |
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◆ Cell & Tissue Lysates | ||
NRG4-1221HCL | Recombinant Human NRG4 cell lysate | +Inquiry |
Not For Human Consumption!
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