Active Recombinant Human NR1H4, His-tagged

• Cat.No.: NR1H4-3066H
• Product Overview: Recombinant Human NR1H4 is expressed inE.Coliwith a His tag at N-terminus. Molecular Weight: 27KDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: The bile acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4) is a nuclear receptor that in humans is encoded by the NR1H4 gene.
• Reagents Supplied: 1x dilution buffer A: 20 mM Tris-Cl (pH 8.0), 20% Glycerol, 100 mM KCl, 0.2 mM EDTA and 1mM DTT.
• Quality Control: The purified recombinant protein is greater than 95% homogeneous based on SDS-PAGE analysis.
• Activity: 1 unit equals 1 nanogram purified protein. 20 units are sufficient for a gel-mobility shift assay and 100 units are sufficient for a protein-protein interaction assay.
• Application: FXR can be used for DNA and protein-protein interactions assays.
• Storage Conditions: Store at -80°C.

Gene Information

• Gene Name: NR1H4 nuclear receptor subfamily 1, group H, member 4 [ Homo sapiens ]
• Synonyms: NR1H4; nuclear receptor subfamily 1, group H, member 4; BAR; FXR; HRR1; HRR-1; RIP14; MGC163445; farnesoid X receptor; Bile acid receptor; Farnesoid X-activated receptor; Farnesol receptor HRR-1; Nuclear receptor subfamily 1 group H member 4; Retinoid X receptor-interacting protein 14; RXR-interacting protein 14; farnesoid X receptor
• Gene ID: 9971
• mRNA Refseq: NM_005123
• Protein Refseq: NP_005114
• MIM: 603826
• UniProt ID: Q96RI1
• Chromosome Location: 12q23.1
• Function: bile acid binding; double-stranded DNA binding; metal ion binding; peptide binding; protein N-terminus binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription coactivator activity; transcription corepressor activity; transcription factor activity; zinc ion binding