Active Recombinant Human NOG Protein, Animal Free

• Cat.No.: NOG-42H
• Product Overview: Recombinant Human NOG Protein without tag was expressed in Human cells.
  Animal Free and Xeno Free

Specification

• Species: Human
• Source: Human Cells
• Description: Noggin belongs to a group of diffusible proteins that bind to ligands of the TGF-β family, and regulate their activity by inhibiting their access to signaling receptors. Noggin is expressed in defined areas of the adult central nervous system and peripheral tissues such as lung, skeletal muscle and skin. Noggin has been shown to modulate the activities of other BMPs, which is required for growth and patterning of the neural tube and somite, and essential for cartilage morphogenesis and joint formation. Noggin also inhibits chondrocyte differentiation through its interaction with GDF5.
• Bio-activity: The activity was measured by the inhibition of BMP-4 induced alkaline phosphatase production in the ATDC-5 cell line (Mouse chondrogenic cell line).
• Molecular Mass: 65 kDa
• Endotoxin: <0.5 EU/ μg
• Purity: High Purity, >95% by SDS-PAGE
• Stability: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -80 centigrade under sterile conditions after reconstitution.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution in PBS without carrier protein
• Reconstitution: Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Gene Information

• Gene Name: NOG noggin [ Homo sapiens (human) ]
• Official Symbol: NOG
• Synonyms: NOG; noggin; SYM1; SYNS1; SYNS1A; noggin; symphalangism 1 (proximal)
• Gene ID: 9241
• mRNA Refseq: NM_005450
• Protein Refseq: NP_005441
• MIM: 602991
• UniProt ID: Q13253