Active Recombinant Human Neurexin 2 Fc-tagged

• Cat.No.: NRXN2-055H
• Product Overview: Recombinant Human NRXN2protein was expressed in CHO with the Fc part of human IgG1 Pro100-Lys330(C-terminus) and Met1-Thr1566 (N-terminus).

Specification

• Species: Human
• Source: CHO
• Tag: Fc
• Protein Length: 1-1566 a.a.
• Description: NRXN2 is a neuronaltype I transmembrane molecule that is encoded by one of three Neurexin genes.Mature human NRXN2 is an approximately 200 kDa N- and O-glycosylated proteinwith a 1608 amino acid (aa extracellular domain (ECD) and a 55 aa cytoplasmicdomain. The ECD contains six LNS domains interspersed with three EGF-likedomains and a juxtamembrane O-glycosylation region. The ECD of human NRXN2shares 98% and 99% aa sequence identity with mouse and rat NRXN2,respectively. Transcription of the NRXN2 gene from an internal promoter givesrise to NRXN2 which lacks the first five LNS domains and all of the EGF-likedomains.
• Form: Lyophilized from a0.2 μm filtered solution in PBS.
• N-terminalSequence: Leu29
• Molecular Weight: 193 kDa
• Activity: Measuredby its binding ability in a functional ELISA. When Recombinant Human NRXN2/NRXN2 Fc Chimera is coated at 2 μg/mL, biotinylatedrecombinant rat NXPH1 binds with an apparent KD < 10 nM.
• Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
• SDS-PAGE: 200-250kDa, reducing conditions
• Purity: >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: Reconstituteat 100 μg/mL in PBS
• Storage: Use a manualdefrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt,-20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70°C under sterile conditions after reconstitution.

Gene Information

• Gene Name: NRXN2 neurexin 2 [ Homosapiens ]
• Official Symbol: NRXN2
• Synonyms: NRXN2; neurexin 2; FLJ40892;KIAA0921; neurexin-2-beta; neurexin II; neurexin II-beta; neurexin-2-alpha;neurexin II-alpha
• Gene ID: 9379
• mRNA Refseq: NM_138734
• Protein Refseq: NP_620063
• MIM: 600566
• UniProt ID: P58401
• Chromosome Location: 11q13
• Pathway: Cell adhesionmolecules (CAMs)
• Function: calcium channelregulator activity; cell adhesion molecule binding; metal ion binding