Active Recombinant Human MMP14, His-tagged

Cat.No. : MMP14-39H
Product Overview : Recombinant Human MMP14(Ala21-Gly284), fused with a C-terminal 10-His tag, was expressed in E. coli.
  • Specification
  • Gene Information
  • Related Products
  • Download
Species : Human
Source : E.coli
Tag : His
Protein Length : 21-284 a.a.
Description : Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
Predicted N Terminal : Ala21
Form : Pro and catalytic domains. Supplied as a 0.2 µm filtered solution in Tris, NaCl, CaCl2, ZnCl2 and Glycerol.
Bio-activity : Measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2.
Molecular Mass : Predicted Molecular Mass:31 kDaSDS-PAGE:31 kDa, reducing conditions
Endotoxin : < 1.0 EU per 1 μg of the protein by the LAL method.
Purity : >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Avoid repeated freeze-thaw cycles.6 months from date of receipt, -20 to -70 °C as supplied.3 months, -20 to -70 °C under sterile conditions after opening.
Gene Name MMP14 matrix metallopeptidase 14 (membrane-inserted) [ Homo sapiens (human) ]
Official Symbol MMP14
Synonyms MMP14; matrixmetallopeptidase 14 (membrane-inserted); 1; MMP-14; MMP-X1;MT-MMP; MT1MMP; MTMMP1; MT1-MMP; MT-MMP 1; matrix metalloproteinase-14;OTTHUMP00000027917; membrane type 1 metalloprotease; membrane-type matrixmetalloproteinase 1; membrane-type-1 matrix metalloproteinase; matrixmetalloproteinase 14 (membrane-inserted)
Gene ID 4323
mRNA Refseq NM_004995
Protein Refseq NP_004986
MIM 600754
UniProt ID P50281
Chromosome Location 14q11.2
Pathway GnRHsignaling pathway; HIF-2-alpha transcription factor network; MatrixMetalloproteinases; Senescence and Autophagy; Signaling events mediated byfocal adhesion kinase
Function calciumion binding; integrin binding; metalloendopeptidase activity; peptidaseactivator activity; protein binding; sequence-specific DNA bindingtranscription factor activity; zinc ion binding

Not For Human Consumption!

Inquiry

  • Reviews
  • Q&As

Customer Reviews (0)

Write a review

Q&As (0)

Ask a question

Ask a Question for All MMP14 Products

Required fields are marked with *

My Review for All MMP14 Products

Required fields are marked with *

0

Inquiry Basket

cartIcon