Active Recombinant Human MAPK14 protein

• Cat.No.: MAPK14-50H
• Product Overview: Recombinant Human MAPK14(M1-S360) was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Protein Length: 1-360 a.a.
• Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
• Form: 50 mM HEPES pH 7.5, 100 mM NaCl, 5 mM DTT, 20% glycerol
• Bio-activity: Specific kinase activity (Pi transfer): 893 pmol/µg×minATP-KM: 2.7 µm
• Molecular Mass: 41,622 Da
• AA Sequence: GAFQSIIHAKRT YRELRLLKHM KHENVIGLLD VFTPARSLEE FNDVYLVTHL MGADLNNIVK MSQERPTF YRQELNKTIW EVPERYQNLS PVGSGAYGSV CAAFDTKTGL RVAVKKLSRPCQKLTDDHVQ FLIYQILRGL KYIHSADIIH RDLKPSNLAV NEDCELKILD FGLARHTDDE MTGYVATRWY RAPEIMLNWM HYNQTVDIWS VGCIMAELLT GRTLFPGTDH INQLQQIMRLTGTPPAYLIN RMPSHEARNY IQSLTQMPKM NFANVFIGAN PLAVDLLEKM LVLDSDKRIT AAQALAHAYF AQYHDPDDEP VADPYDQSFE SRDLLIDEWK SLTYDEVISF VPPPLDQEEMES
• Storage: Storage temperature: -80 centigrade.For complete recovery, mix well and spin before use. Product must not be stored in diluted solutions, aliquots below 10µl are not advisable. Avoid repeated freeze-thaw cycles!
• Concentration: 0.311 µg/µl

Gene Information

• Gene Name: MAPK14 mitogen-activated protein kinase 14 [ Homo sapiens ]
• Official Symbol: MAPK14
• Synonyms: MAPK14; mitogen-activated protein kinase 14; CSBP1, CSBP2, CSPB1; Mxi2; p38; p38 MAP kinase; PRKM14; PRKM15; MAP kinase 14; p38alpha Exip; MAP kinase Mxi2; MAP kinase p38 alpha; CSAID-binding protein; Csaids binding protein; MAX-interacting protein 2; stress-activated protein kinase 2A; p38 mitogen activated protein kinase; mitogen-activated protein kinase p38 alpha; cytokine suppressive anti-inflammatory drug binding protein; cytokine suppressive anti-inflammatory drug-binding protein; RK; CSBP; EXIP; CSBP1; CSBP2; CSPB1; SAPK2A; p38ALPHA
• Gene ID: 1432
• mRNA Refseq: NM_001315
• Protein Refseq: NP_001306
• MIM: 600289
• UniProt ID: Q16539
• Chromosome Location: 6p21.3-p21.2
• Pathway: ADP signalling through P2Y purinoceptor 1, organism-specific biosystem; ATF-2 transcription factor network, organism-specific biosystem; Activated TLR4 signalling, organism-specific biosystem; Activation of the AP-1 family of transcription factors, organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem
• Function: ATP binding; MAP kinase activity; MAP kinase kinase activity; NFAT2 protein binding; nucleotide binding; protein binding; protein serine/threonine kinase activity