Active Recombinant Human KREMEN1, Fc-tagged

• Cat.No.: KREMEN1-633H
• Product Overview: The recombinant human KREMEN1-Fc fusion is expressed as a 593 amino acid protein consisting of Arg21 - Gly375 region of KREMEN1 (Uniprot Accession #Q96MU8-3) and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.

Specification

• Source: Human cells
• Species: Human
• Tag: Fc
• Form: Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier and preservative free).
• Bio-activity: Recombinant KREMEN1-Fc binds human Dkk1 with high affinity (apparent KD< 10 nM)
• Molecular Mass: Calculated molecular mass (kDa): 65.8; Estimated by SDS-PAGE under reducing condition (kDa): 80-90.
• Endotoxin: <0.1 eu="" per="" 1="" μg="" of="" purified="" recombinant="" protein="" determined="" by="" the="" lal="">
• Purity: >90% judged by SDS-PAGE under reducing condition
• Storage: The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.
• Protein length: 21-375 a.a.

Gene Information

• Gene Name: KREMEN1 kringle containing transmembrane protein 1 [ Homo sapiens ]
• Official Symbol: KREMEN1
• Synonyms: KREMEN1; kringle containing transmembrane protein 1; KREMEN, kringle containing transmembrane protein; kremen protein 1; KRM1; dickkopf receptor; kringle-coding gene marking the eye and the nose; kringle domain-containing transmembrane protein 1; kringle-containing protein marking the eye and the nose; KREMEN; FLJ31863
• Gene ID: 83999
• mRNA Refseq: NM_001039570
• Protein Refseq: NP_001034659
• MIM: 609898
• UniProt ID: Q96MU8
• Chromosome Location: 22q12.1
• Pathway: Wnt signaling network, organism-specific biosystem
• Function: protein binding