Active Recombinant Human interleukin 8, MIgG2a Fc-tagged

• Cat.No.: CXCL8-323H
• Product Overview: The extracellular domain of human IL-8 (NP_000575.1)(Ala23-Ser99) is fused to the N-terminus of the Fc portion of mouse IgG2a was expressed in CHO cell.

Specification

• Species: Human
• Source: CHO
• Tag: Fc
• ProteinLength: 23-99 a.a.
• Description: The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its chemotaxis of human CXCR-2 transfected mouse BaF/3 cells.
• Molecular Mass: 37 KDa (monomer)
• AA Sequence: Ala23-Ser99
• Endotoxin: <0.06 eu/μg="" as="" determined="" by="" lal="" test.="">
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: CXCL8
• Official Symbol: CXCL8
• Synonyms: IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1
• Gene ID: 3576
• mRNA Refseq: NM_000584
• Protein Refseq: NP_000575
• MIM: 146930
• UniProt ID: P10145
• Chromosome Location: 4q13-q21
• Pathway: ATF-2 transcription factor network, organism-specific biosystem; Activation of Genes by ATF4, organism-specific biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem
• Function: chemokine activity; interleukin-8 receptor binding; protein binding