Active Recombinant Human IL1RN Protein

Description :	Interleukin-1 receptor antagonist (IL-1RA) binds the interleukin 1 receptor (IL-1R) to antagonize interleukin 1 alpha and beta signaling. IL-1RA is secreted by immune cells, epithelial cells, hepatocytes, and adipocytes to inhibit IL-1-induced inflammation. IL-1RA therapy is used to treat auto-inflammatory diseases such as diabetes and rheumatoid arthritis.
Source :	E. coli
Species :	Human
Bio-activity :	Inhibition of human IL-1 alpha induced proliferation of D10.G4.1 cells, ED50≤50 ng/mL
Molecular Mass :	17.3 kDa (with 153 amino acids)
AA Sequence :	MRPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE
Endotoxin :	≤1 EUs/μg, Kinetic LAL (50% confidence)
Purity :	≥95%, Reducing and Non-Reducing SDS PAGE
Stability :	12 months from date of receipt when stored at -20 to -80 centigrade as supplied. 1 month when stored at 4 centigrade after reconstituting as directed. 3 months when stored at -20 to -80 centigrade after reconstituting as directed.
Storage :	Storage Prior to Reconstitution: -20 centigrade
Storage Buffer :	Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5
Reconstitution :	Sterile water at 0.1 mg/mL
Shipping :	Room temperature
Instructions :	Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80 centigrade and avoid repeat freeze thaws.

Gene Name	IL1RN interleukin 1 receptor antagonist [ Homo sapiens (human) ]
Official Symbol	IL1RN
Synonyms	IL1RN; interleukin 1 receptor antagonist; interleukin-1 receptor antagonist protein; ICIL 1RA; IL 1RN; IL1F3; IL1RA; interleukin 1 receptor antagonist protein; intracellular interleukin 1 receptor antagonist; IRAP; MGC10430; IL1 inhibitor; IL1RN (IL1F3); type II interleukin-1 receptor antagonist; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); DIRA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA;
Gene ID	3557
mRNA Refseq	NM_000577
Protein Refseq	NP_000568
MIM	147679
UniProt ID	P18510