Active Recombinant Human IL17A
Cat.No. : | IL17A-333H |
Product Overview : | Human IL17A (Q16552, 20 a.a.-134 a.a.) partial recombinant protein expressed in Escherichia coli. |
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Species : | Human |
Source : | Human |
Tag : | Non |
Description : | Interleukin-17A is a protein that in humans is encoded by the IL17A gene. The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. |
Sequence : | I PTEIPTSALV KETLALLSTH RTLLIANETL RIPVPVHKNH QLCTEEIFQG IGTLESQTVQ GGTVERLFKN LSLIKKYIDG QKKKCGEERR RVNQFLDYLQ EFLGVMNTEW IIES |
Theoretical MW (kDa) : | 16 |
Form : | Lyophilized |
Preparation Method : | Escherichia coli expression system |
Purity : | > 95% by SDS-PAGE and HPLC |
Endotoxin Level : | < 0.1 ng/ug (1 EU/ug) |
Activity : | The ED50 was determined by the dose-dependent proliferation of induction of IL-6 in primary human foreskin fibroblasts was found to be approximately 2 ng/mL., corresponding to a specific activity of < 5 x 105 units/mg. |
Application : | SDS-PAGE |
Storage Buffer : | Lyophilized from PBS, pH 7.5 |
Storage : | Store at -20°C on dry atmosphere for 2 years. After reconstitution with deionized water, store at 4°C for 1 month or store at -20°C for 6 months. Aliquot to avoid repeated freezing and thawing. |
Unitprot ID : | Q16552 |
Pathways : | Cytokine-cytokine receptor interaction |
Gene Name | 17A interleukin 17A [ Homo sapiens ] |
Official Symbol | IL12B |
Synonyms | IL17A; interleukin 17A; IL17; CTLA8; IL-17; IL-17A; toxic T-lymphocyte-associated antigen 8; otoxic T-lymphocyte-associated protein 8; cytotoxic T-lymphocyte-associated serine esterase 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8) |
Gene ID | 3605 |
mRNA Refseq | NM_002190 |
Protein Refseq | NP_002181 |
MIM | 603149 |
Chromosome Location | 6p12 |
Function | Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts. |
◆ Recombinant Proteins | ||
IL17A&IL17F-165H | Active Recombinant Human IL17A/IL17F Protein, Biotinylated | +Inquiry |
IL17A-254I | Active Recombinant Human IL17A Protein (142 aa), His-tagged | +Inquiry |
IL17A-2293H | Recombinant Human IL17A Protein, His-tagged | +Inquiry |
IL17A-425M | Active Recombinant Marmoset IL17A protein | +Inquiry |
IL17A-333H | Active Recombinant Human IL17A | +Inquiry |
◆ Cell & Tissue Lysates | ||
IL17A-001HCL | Recombinant Human IL17A cell lysate | +Inquiry |
Not For Human Consumption!
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