Active Recombinant Human HDAC10 protein, FLAG-tagged

• Cat.No.: HDAC10-393H
• Product Overview: Recombinant Human HDAC10(a.a. 2-631) fused with FLAG tag at N-terminal was expressed in Insect cells.

Specification

• Description: The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Source: Insect cells
• Species: Human
• Tag: FLAG
• Form: 45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 0.05% Tween-20 and 10% glycerol.
• Bio-activity: ≥3.6 pmol/min/μg.
• Molecular Mass: 67 kDa
• Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Storage: >6 months at -80 centigrade. Avoid freeze/thaw cycles.
• Concentration: 0.15 mg/ml
• Protein length: 2-631 a.a.

Gene Information

• Gene Name: HDAC10 histone deacetylase 10 [ Homo sapiens ]
• Official Symbol: HDAC10
• Synonyms: HDAC10; histone deacetylase 10; DKFZP761B039; HD10; MGC149722; DKFZp761B039
• Gene ID: 83933
• mRNA Refseq: NM_032019
• Protein Refseq: NP_114408
• MIM: 608544
• UniProt ID: Q969S8
• Chromosome Location: 22q13.31
• Pathway: NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by NOTCH, organism-specific biosystem; Signaling by NOTCH1, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class II, organism-specific biosystem
• Function: NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); enzyme binding; histone deacetylase activity; histone deacetylase activity (H3-K16 specific); histone deacetylase binding; hydrolase activity; protein binding; protein deacetylase activity