Active Recombinant Human GDF9 Protein

• Cat.No.: GDF9-053H
• Product Overview: The mature recombinant human GDF-9 protein (320-454aa) without tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Protein Length: 320-454 a.a.
• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates ovarian function. Reduced expression of this gene may be associated with polycystic ovary syndrome and mutations in this gene may be more common in mothers of dizygotic twins.
• Bio-activity: Measured by its ability to induce cell death using Mv1Lu mink lung epithelial cells. The ED50 for this effect is 50-250 ng/mL.
• Molecular Mass: 16 kDa
• Product-Related Proteins: 320-454
• Endotoxin: < 0.1 EU/μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS

Gene Information

• Gene Name: GDF9 growth differentiation factor 9 [ Homo sapiens (human) ]
• Official Symbol: GDF9
• Synonyms: GDF9; growth differentiation factor 9; POF14; growth/differentiation factor 9
• Gene ID: 2661
• mRNA Refseq: NM_005260
• Protein Refseq: NP_005251
• MIM: 601918
• UniProt ID: O60383