Active Recombinant Human GDF11 Protein

• Cat.No.: GDF11-046H
• Product Overview: The mature recombinant human GDF-11 protein (299-407aa) without tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Protein Length: 299-407 a.a.
• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging.
• Bio-activity: Measured by its ability to induce hemoglobin expression in K562 human chronic myelogenous leukemia cells. The ED50 for this effect is 0.8-4.8 ng/mL.
• Molecular Mass: 12.6 kDa
• Product-Related Proteins: 299-407
• Endotoxin: < 0.1 EU/μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS

Gene Information

• Gene Name: GDF11 growth differentiation factor 11 [ Homo sapiens (human) ]
• Official Symbol: GDF11
• Synonyms: GDF11; growth differentiation factor 11; VHO; BMP11; BMP-11; growth/differentiation factor 11; GDF-11; bone morphogenetic protein 11
• Gene ID: 10220
• mRNA Refseq: NM_005811
• Protein Refseq: NP_005802
• MIM: 603936
• UniProt ID: O95390