Active Recombinant Human FOS-like Antigen 1

• Cat.No.: FOSL1-1034H

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: The fos-related antigen 1 (Fra-1, or FosL1: Fos-like antigen 1) is a member of the Fos onco-protein family and a component of AP-1 transcription factor. Similar to other members of the family, Fra-1 contains a leucine zipper domain and a highly conserved C-terminal region. Transcription of Fra-1 gene is regulated by multiple cis-elements and 12-O-tetradecanoylphorbol-13-acetate (TPA). Fra-1 expression is associated with proliferation and invasiveness of breast cancer cells and other cancer cells.
• Form: Liquid. Supplied in 20 mM Tris-HCl pH 8.0, 20% glycerol, 100 mM KCl, 0.2 mM EDTA and 1 mM DTT.
• Purity: > 95% by SDS-PAGE.
• Activity: 20-200 ng are sufficient for an in vitro transcription assay and 100 ng are sufficient for a protein-protein interaction assay.
• Application: Use only for research. FRA-1 can be applied in in vitro transcription assays, DNA-protein and protein-protein interaction assays.
• Usage: For in vitro use only.
• Storage: Quality guaranteed for 12 months store at - 80°C. Avoid freeze / thaw cycles

Gene Information

• Gene Name: FOSL1 FOS-like antigen 1 [ Homo sapiens ]
• Synonyms: FOSL1; FOS-like antigen 1; FRA; FRA1; fra-1; FOS-like antigen-1; Fos-related antigen; FRA-1
• Gene ID: 8061
• mRNA Refseq: NM_005438
• Protein Refseq: NP_005429
• MIM: 136515
• UniProt ID: P15407
• Chromosome Location: 11q13
• Pathway: Wnt signaling pathway
• Function: protein dimerization activity; sequence-specific DNA binding; transcription activator activity; transcription factor activity