Active Recombinant Human FGR Protein, GST/His-tagged

• Cat.No.: FGR-4155H
• Product Overview: Human FGR (NM_005248.1, 1 a.a. - 529 a.a.) full-length recombinant protein with GST-His tag expressed in Sf9 cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST&His
• Description: This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq
• Form: Liquid
• Bio-activity: 16 pmol/μg x min
• Molecular Mass: 93.934 kDa
• Applications: Functional Study
  SDS-PAGE
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Concentration: 0.055 μg/μL
• Storage Buffer: In 50 mM Tris-HCl, 100 mM NaCl, pH 8.0 (5 mM DTT, 4 mM reduced glutathione, 20% glycerol)

Gene Information

• Gene Name: FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog [ Homo sapiens ]
• Official Symbol: FGR
• Synonyms: FGR; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; SRC2; tyrosine-protein kinase Fgr; c fgr; p55c fgr; p55-c-fgr protein; c-fgr protooncogene; proto-oncogene c-Fgr; c-src-2 proto-oncogene; proto-oncogene tyrosine-protein kinase FGR; c-fgr; c-src2; p55-Fgr; p58-Fgr; p55c-fgr; p58c-fgr; FLJ43153; MGC75096
• Gene ID: 2268
• mRNA Refseq: NM_001042729
• Protein Refseq: NP_001036194
• MIM: 164940
• UniProt ID: P09769