Active Recombinant Human EGF, MIgG2a Fc-tagged

Description :	This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as alarge precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factorpeptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferationand differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor,epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation ofthis gene has been associated with the growth and progression of certain cancers. Alternate splicing results inmultiple transcript variants.
Source :	CHO cell
Species :	Human
Tag :	MIgG2a Fc-tagged
Form :	Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity :	Measured in a cell proliferation assay using MC/9‑2 mouse mast cells.
Molecular Mass :	32KDa (monomer)
AA Sequence :	Asn974-Arg1026
Endotoxin :	<0.06 eu/μg="" as="" determined="" by="" lal="" test.="">
Purity :	>98%, by SDS-PAGE under reducing conditions.
Stability :	Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution :	Reconstitute at 100μg/ml in sterile PBS.
Warning :	Avoid freeze/thaw cycles.
Protein length :	974-1026 a.a.

Gene Name	EGF epidermal growth factor [ Homo sapiens ]
Official Symbol	EGF
Synonyms	EGF; epidermal growth factor; epidermal growth factor (beta urogastrone); pro-epidermal growth factor; beta-urogastrone; URG; HOMG4;
Gene ID	1950
mRNA Refseq	NM_001178130
Protein Refseq	NP_001171601
MIM	131530
UniProt ID	P01133
Chromosome Location	4q25
Pathway	Arf6 signaling events, organism-specific biosystem; Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Ceramide signaling pathway, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem;
Function	calcium ion binding; epidermal growth factor receptor binding; growth factor activity; protein binding; transmembrane receptor protein tyrosine kinase activator activity;

COA

Cat.No. :	EGF-550H
Product Overview :	The extracellular domain of rat EGF(NP_036974.1)(Asn974-Arg1026) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO cell.