Active Recombinant Human DUSP22, GST-tagged

• Cat.No.: DUSP22-1514H
• Product Overview: Recombinant full length human DUSP22 was expressed in E.coli cells using a N-terminal GST tag.

Specification

• Description: Dual specificity phosphatases (DUSP) family, which can dephosphorylate both phosphoserine/threonine and phosphotyrosine residues, comprise of two subgroups: "typical" DUSP (include 11 MKPs that dephosphorylate the mitogen-activated protein kinases Erk, Jnk, and p38 at their dually phosphorylated TXY activation loop motif) and "atypical" DUSP (include 8 enzymes that lack specific MAP kinase-targeting motifs and tend to be much smaller proteins, which are less than 250 amino acid residues).DUSP22, also called JKAP, JSP1 and MKPX plays a role in various inflammatory and proliferative disorders associated with dysfunctional Jnk signaling.
• Source: Sf9 Cells
• Species: Human
• Tag: GST
• Form: Recombinant protein stored in 20mM MOPS, pH 7.5, 50mM NaCl, 10mM glutathione, 0.25mM DTT, 0.1mM PMSF, 30% glycerol.
• Bio-activity: 600 nmol/min/mg
• Molecular Mass: ~43 kDa
• Protein length: Full length
• Purity: >90%
• Applications: Phosphatase Assay, Western Blot
• Storage: Store at–70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: DUSP22 dual specificity phosphatase 22 [ Homo sapiens ]
• Official Symbol: DUSP22
• Synonyms: DUSP22; dual specificity phosphatase 22; dual specificity protein phosphatase 22; JKAP; JSP1; MKPX; VHX; JSP-1; MKP-x; LMW-DSP2; MAP kinase phosphatase x; JNK-stimulating phosphatase 1; JNK-stimulatory phosphatase-1; mitogen-activated protein kinase phosphatase x; low molecular weight dual specificity phosphatase 2; homolog of mouse dual specificity phosphatase LMW-DSP2; LMWDSP2; FLJ35864
• Gene ID: 56940
• mRNA Refseq: NM_020185
• Protein Refseq: NP_064570
• UniProt ID: Q9NRW4
• Chromosome Location: 6pter-q22.33
• Pathway: MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, conserved biosystem
• Function: hydrolase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity